SLA1/YBL007C Summary Help

Standard Name SLA1 1
Systematic Name YBL007C
Feature Type ORF, Verified
Description Cytoskeletal protein binding protein; required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains (2, 3, 4, 5)
Name Description Synthetic Lethal with ABP1 1
Chromosomal Location
ChrII:216366 to 212632 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All SLA1 GO evidence and references
  View Computational GO annotations for SLA1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 3 genes
Resources
Classical genetics
null
overexpression
unspecified
Large-scale survey
null
unspecified
Resources
703 total interaction(s) for 414 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 47
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 23
  • Biochemical Activity: 17
  • Co-crystal Structure: 1
  • Co-fractionation: 1
  • Co-localization: 1
  • Co-purification: 1
  • FRET: 2
  • PCA: 7
  • Protein-peptide: 1
  • Reconstituted Complex: 16
  • Two-hybrid: 140

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Lethality: 5
  • Dosage Rescue: 1
  • Negative Genetic: 328
  • Phenotypic Enhancement: 6
  • Phenotypic Suppression: 2
  • Positive Genetic: 29
  • Synthetic Growth Defect: 28
  • Synthetic Lethality: 42
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,244
Molecular Weight (Da) 135,847
Isoelectric Point (pI) 5.69
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:216366 to 212632 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..3735 216366..212632 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000103
References cited on this page View Complete Literature Guide for SLA1
1) Holtzman DA, et al.  (1993) Synthetic-lethal interactions identify two novel genes, SLA1 and SLA2, that control membrane cytoskeleton assembly in Saccharomyces cerevisiae. J Cell Biol 122(3):635-44
2) Pruyne D and Bretscher A  (2000) Polarization of cell growth in yeast. J Cell Sci 113 ( Pt 4):571-85
3) Howard JP, et al.  (2002) Sla1p serves as the targeting signal recognition factor for NPFX(1,2)D-mediated endocytosis. J Cell Biol 157(2):315-26
4) Warren DT, et al.  (2002) Sla1p couples the yeast endocytic machinery to proteins regulating actin dynamics. J Cell Sci 115(Pt 8):1703-15
5) Gardiner FC, et al.  (2007) Nucleocytoplasmic trafficking is required for functioning of the adaptor protein sla1p in endocytosis. Traffic 8(4):347-58