Standard Name	YAR1
Systematic Name	YPL239W
Feature Type	ORF, Verified
Description	Ankyrin-repeat containing, nucleocytoplasmic shuttling chaperone; prevents aggregation of Rps3p in the cytoplasm, associates with free Rps3p in the cytoplasm and delivers it to the 90S in the nucleus; required for 40S ribosomal subunit export, biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock (1, 2, 3, 4)
Name Description	Yeast Ankyrin Repeat 1

Chromosomal Location	ChrXVI:99484 to 100086 | ORF Map | GBrowse

Molecular Function
Manually curated	unfolded protein binding (IMP)
Biological Process
Manually curated	cellular response to oxidative stress (IMP) regulation of protein localization (IMP, IPI) response to osmotic stress (IMP) ribosomal small subunit biogenesis (IGI, IMP) ribosomal small subunit export from nucleus (IGI, IMP)
Cellular Component
Manually curated	nucleus (IDA, IGI)
High-throughput	cytoplasm (IDA)

Classical genetics
null	35S pre-rRNA accumulation: increased aberrant 23S RNA intermediate accumulation: increased 20S pre-rRNA accumulation: increased tellurium atom accumulation: increased cold sensitivity: increased hyperosmotic stress resistance: decreased oxidative stress resistance: decreased 40S ribosomal subunit accumulation: decreased 60S ribosomal subunit accumulation: increased resistance to tellurite: increased resistance to cycloheximide: normal resistance to anisomycin: decreased resistance to neomycin: decreased resistance to paromomycin: decreased starvation resistance: normal vegetative growth: decreased
Large-scale survey
null	competitive fitness: decreased endocytosis: decreased fermentative growth: decreased rate heat sensitivity: increased resistance to streptomycin: decreased resistance to cycloheximide: decreased resistance to sodium arsenite: increased resistance to citric acid: decreased resistance to doxorubicin: decreased starvation resistance: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	88 total interaction(s) for 59 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Affinity Capture-RNA: 2 Affinity Capture-Western: 2 Co-purification: 1 Protein-peptide: 1 Reconstituted Complex: 2 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 60 Positive Genetic: 12 Synthetic Growth Defect: 2 Synthetic Lethality: 2 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:99484 to 100086 | ORF Map | GBrowse
Last Update	Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..603 99484..100086 1996-07-31 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000006160