SWH1/YAR042W Summary Help

Standard Name SWH1 1
Systematic Name YAR042W
Alias YAR044W , OSH1 2
Feature Type ORF, Verified
Description Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction; SWH1 has a paralog, OSH2, that arose from the whole genome duplication (1, 3, 4, 5)
Chromosomal Location
ChrI:192619 to 196185 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SWH1 GO evidence and references
  View Computational GO annotations for SWH1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant phenotypes All SWH1 Phenotype evidence and references
Classical genetics
null
Large-scale survey
null
Resources
interactions All SWH1 Interaction evidence and references
78 total interaction(s) for 57 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 20
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 2
  • Co-localization: 1
  • PCA: 3
  • Protein-RNA: 1
  • Two-hybrid: 1
Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 1
  • Negative Genetic: 35
  • Phenotypic Enhancement: 2
  • Positive Genetic: 5
  • Synthetic Growth Defect: 4
Resources
Expression Summary
histogram
Resources
Protein Information All SWH1 Protein evidence and references
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrI:192619 to 196185 | ORF Map | GBrowse
This feature contains embedded feature(s): YAR044W
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2006-01-19
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..3567 192619..196185 2011-02-03 2006-01-19
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez)
Primary SGDIDS000000081
References cited on this page View Complete Literature Guide for SWH1
1) Schmalix WA and Bandlow W  (1994) SWH1 from yeast encodes a candidate nuclear factor containing ankyrin repeats and showing homology to mammalian oxysterol-binding protein. Biochim Biophys Acta 1219(1):205-10
2) Beh CT, et al.  (2001) Overlapping functions of the yeast oxysterol-binding protein homologues. Genetics 157(3):1117-40
3) Jiang B, et al.  (1994) A new family of yeast genes implicated in ergosterol synthesis is related to the human oxysterol binding protein. Yeast 10(3):341-53
4) Levine TP and Munro S  (2001) Dual targeting of Osh1p, a yeast homologue of oxysterol-binding protein, to both the Golgi and the nucleus-vacuole junction. Mol Biol Cell 12(6):1633-44
5) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61