SWH1/YAR042W Summary Help

Standard Name SWH1 1
Systematic Name YAR042W
Alias YAR044W , OSH1 2
Feature Type ORF, Verified
Description Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction; SWH1 has a paralog, OSH2, that arose from the whole genome duplication (1, 3, 4, 5)
Chromosomal Location
ChrI:192619 to 196185 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SWH1 GO evidence and references
  View Computational GO annotations for SWH1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 2 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
85 total interaction(s) for 61 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 21
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 2
  • Co-localization: 1
  • PCA: 4
  • Protein-RNA: 1
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 1
  • Negative Genetic: 40
  • Phenotypic Enhancement: 2
  • Positive Genetic: 5
  • Synthetic Growth Defect: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,188
Molecular Weight (Da) 135,096
Isoelectric Point (pI) 5.34
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrI:192619 to 196185 | ORF Map | GBrowse
This feature contains embedded feature(s): YAR044W
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2006-01-19
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..3567 192619..196185 2011-02-03 2006-01-19
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez)
Primary SGDIDS000000081
References cited on this page View Complete Literature Guide for SWH1
1) Schmalix WA and Bandlow W  (1994) SWH1 from yeast encodes a candidate nuclear factor containing ankyrin repeats and showing homology to mammalian oxysterol-binding protein. Biochim Biophys Acta 1219(1):205-10
2) Beh CT, et al.  (2001) Overlapping functions of the yeast oxysterol-binding protein homologues. Genetics 157(3):1117-40
3) Jiang B, et al.  (1994) A new family of yeast genes implicated in ergosterol synthesis is related to the human oxysterol binding protein. Yeast 10(3):341-53
4) Levine TP and Munro S  (2001) Dual targeting of Osh1p, a yeast homologue of oxysterol-binding protein, to both the Golgi and the nucleus-vacuole junction. Mol Biol Cell 12(6):1633-44
5) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61