CDC15/YAR019C Summary Help

Standard Name CDC15 1
Systematic Name YAR019C
Alias LYT1
Feature Type ORF, Verified
Description Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress (2, 3, 4)
Name Description Cell Division Cycle 5
Chromosomal Location
ChrI:175135 to 172211 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: 6 cM
Gene Ontology Annotations All CDC15 GO evidence and references
  View Computational GO annotations for CDC15
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
High-throughput
Cellular Component
Manually curated
High-throughput
Regulators 6 genes
Resources
Classical genetics
conditional
Large-scale survey
null
reduction of function
repressible
Resources
177 total interaction(s) for 101 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 7
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 9
  • Biochemical Activity: 33
  • Co-localization: 6
  • Reconstituted Complex: 7
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Lethality: 6
  • Dosage Rescue: 37
  • Phenotypic Enhancement: 11
  • Phenotypic Suppression: 12
  • Positive Genetic: 1
  • Synthetic Growth Defect: 14
  • Synthetic Lethality: 17
  • Synthetic Rescue: 13

Resources
Expression Summary
histogram
Resources
Length (a.a.) 974
Molecular Weight (Da) 110,241
Isoelectric Point (pI) 8
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrI:175135 to 172211 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Genetic position: 6 cM
Last Update Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2925 175135..172211 2011-02-03 2011-02-03
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000072
References cited on this page View Complete Literature Guide for CDC15
1) Cid, V.J. and M.Sanchez  (1997) LYT1 is allelic to CDC15. Unpublished results
2) Bardin AJ, et al.  (2003) Mitotic exit regulation through distinct domains within the protein kinase Cdc15. Mol Cell Biol 23(14):5018-30
3) Pablo-Hernando ME, et al.  (2007) Cdc15 is required for spore morphogenesis independently of Cdc14 in Saccharomyces cerevisiae. Genetics 177(1):281-93
4) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
5) Hartwell LH, et al.  (1970) Genetic control of the cell-division cycle in yeast. I. Detection of mutants. Proc Natl Acad Sci U S A 66(2):352-9