SWD1/YAR003W Summary Help

Standard Name SWD1 1
Systematic Name YAR003W
Alias FUN16 2 , CPS50 3 , SAF49 4
Feature Type ORF, Verified
Description Subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7 (1, 3, 4, 5, 6, 7)
Name Description Set1c, WD40 repeat protein
Chromosomal Location
ChrI:155005 to 156285 | ORF Map | GBrowse
Gene Ontology Annotations All SWD1 GO evidence and references
  View Computational GO annotations for SWD1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Classical genetics
Large-scale survey
469 total interaction(s) for 247 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 55
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 6
  • Biochemical Activity: 5
  • Co-crystal Structure: 1
  • Co-purification: 2
  • Protein-RNA: 1
  • Reconstituted Complex: 3
  • Two-hybrid: 3

Genetic Interactions
  • Negative Genetic: 259
  • Phenotypic Enhancement: 4
  • Phenotypic Suppression: 3
  • Positive Genetic: 47
  • Synthetic Growth Defect: 46
  • Synthetic Lethality: 25
  • Synthetic Rescue: 8

Expression Summary
Length (a.a.) 426
Molecular Weight (Da) 48,654
Isoelectric Point (pI) 4.52
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrI:155005 to 156285 | ORF Map | GBrowse
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..1281 155005..156285 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000064
References cited on this page View Complete Literature Guide for SWD1
1) Roguev A, et al.  (2001) The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4. EMBO J 20(24):7137-48
2) Steensma HY, et al.  (1987) Molecular cloning of chromosome I DNA from Saccharomyces cerevisiae: isolation and analysis of the CEN1-ADE1-CDC15 region. Mol Cell Biol 7(1):410-9
3) Miller T, et al.  (2001) COMPASS: a complex of proteins associated with a trithorax-related SET domain protein. Proc Natl Acad Sci U S A 98(23):12902-7
4) Nagy PL, et al.  (2002) A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3. Proc Natl Acad Sci U S A 99(1):90-4
5) Krogan NJ, et al.  (2002) COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression. J Biol Chem 277(13):10753-5
6) Dover J, et al.  (2002) Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6. J Biol Chem 277(32):28368-71
7) Cheng H, et al.  (2004) The essential WD repeat protein Swd2 has dual functions in RNA polymerase II transcription termination and lysine 4 methylation of histone H3. Mol Cell Biol 24(7):2932-43