Standard Name	SPC72
Systematic Name	YAL047C
Alias	LDB4
Feature Type	ORF, Verified
Description	Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules; has roles in astral microtubule formation and stabilization (1, 2, 3)
Name Description	Spindle Pole Component

Chromosomal Location	ChrI:56857 to 54989 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for SPC72
Molecular Function
Manually curated	structural constituent of cytoskeleton (IPI)
Biological Process
Manually curated	microtubule nucleation (IMP) mitotic sister chromatid segregation (IMP) mitotic spindle elongation (IMP) mitotic spindle orientation checkpoint (IGI, IPI) nuclear migration along microtubule (IMP)
Cellular Component
Manually curated	outer plaque of spindle pole body (IDA)

Classical genetics
null	metal resistance: decreased
reduction of function	budding index: abnormal
Large-scale survey
null	acid pH resistance: decreased alkaline pH resistance: decreased bud morphology: abnormal cell size: increased glutathione excretion: increased competitive fitness: decreased endocytosis: decreased heat sensitivity: increased resistance to methanol: decreased resistance to doxorubicin: decreased resistance to hydroxyurea: decreased resistance to mycophenolic acid: decreased resistance to sulfanilamide: decreased resistance to cycloheximide: decreased resistance to amitrole: decreased resistance to propan-1-ol: decreased resistance to arsenite(3-): decreased resistance to benomyl: decreased resistance to caffeine: decreased resistance to sirolimus: decreased resistance to sulfometuron methyl: decreased resistance to wortmannin: decreased resistance to (S)-lactic acid: decreased resistance to hydrogen chloride: decreased resistance to pyrrolidine dithiocarbamate: decreased resistance to boric acid: decreased resistance to ethanol: decreased resistance to 1,4-dithiothreitol: decreased resistance to sorbate: decreased respiratory growth: absent transposable element transposition: decreased vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	190 total interaction(s) for 124 unique genes/features.
Physical Interactions	Affinity Capture-MS: 13 Affinity Capture-Western: 13 Biochemical Activity: 3 Co-localization: 3 Co-purification: 1 FRET: 2 PCA: 6 Protein-peptide: 1 Reconstituted Complex: 9 Two-hybrid: 124
Genetic Interactions	Dosage Rescue: 3 Synthetic Growth Defect: 9 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrI:56857 to 54989 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1869 56857..54989 2011-02-03 2011-02-03
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000045