GIP4/YAL031C Summary

GIP4 BASIC INFORMATION

Standard Name	GIP4 1
Systematic Name	YAL031C
Alias	FUN21 2
Feature Type	ORF, Verified
Description	Cytoplasmic Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; potential Cdc28p substrate (1, 3, 4)
Name Description	Glc7 Interacting Protein 1

GO Annotations	All GIP4 GO evidence and references
	View Computational GO annotations for GIP4
Molecular Function
Manually curated	protein phosphatase 1 binding (IDA) protein phosphatase type 1 regulator activity (IMP)
Biological Process
Manually curated	chromosome segregation (IMP) regulation of phosphoprotein phosphatase activity (IMP)
Cellular Component
High-throughput	cytoplasm (IDA)

Mutant Phenotype	All GIP4 Phenotype details and references
Classical genetics
null	viable
overexpression	actin cytoskeleton morphology: abnormal budding index: abnormal cellular morphology: abnormal nuclear morphology: abnormal
Large-scale survey
null	hyperosmotic stress resistance: decreased viable
overexpression	vegetative growth: decreased

Interactions	GIP4 All interactions details and references
	13 total interaction(s) for 12 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-RNA: 2 Biochemical Activity: 2 Two-hybrid: 3
Genetic Interactions	Dosage Rescue: 2 Synthetic Growth Defect: 2

Sequence Information

ChrI:87032 to 84750 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2004-07-20 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2283	87032..84750	2004-07-20	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000029

GIP4 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for GIP4

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for GIP4]

1)	Pinsky BA, et al. (2006) Glc7/protein phosphatase 1 regulatory subunits can oppose the Ipl1/aurora protein kinase by redistributing Glc7. Mol Cell Biol 26(7):2648-60
2)	Diehl BE and Pringle JR (1991) Molecular analysis of Saccharomyces cerevisiae chromosome I: identification of additional transcribed regions and demonstration that some encode essential functions. Genetics 127(2):287-98
3)	Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
4)	Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64

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