TFC3/YAL001C Summary Help

Standard Name TFC3 1
Systematic Name YAL001C
Alias FUN24 2 , TSV115 3 , 4
Feature Type ORF, Verified
Description Subunit of RNA polymerase III transcription initiation factor complex; part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding; largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC) (1, 5, 6, 7)
Name Description Transcription Factor class C 1
Gene Product Alias tau 138 1
Chromosomal Location
ChrI:151166 to 147594 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Genetic position: -1 cM
Gene Ontology Annotations All TFC3 GO evidence and references
  View Computational GO annotations for TFC3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Classical genetics
Large-scale survey
62 total interaction(s) for 39 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 28
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 11
  • Co-fractionation: 1
  • Far Western: 1

Genetic Interactions
  • Dosage Rescue: 16
  • Synthetic Lethality: 1
  • Synthetic Rescue: 2

Expression Summary
Length (a.a.) 1,160
Molecular Weight (Da) 132,107
Isoelectric Point (pI) 10.16
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrI:151166 to 147594 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Genetic position: -1 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..70 151166..151097 2011-02-03 1996-07-31
Intron 71..160 151096..151007 2011-02-03 1996-07-31
CDS 161..3573 151006..147594 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000001
References cited on this page View Complete Literature Guide for TFC3
1) Lefebvre O, et al.  (1992) TFC3: gene encoding the B-block binding subunit of the yeast transcription factor IIIC. Proc Natl Acad Sci U S A 89(21):10512-6
2) Clark MW, et al.  (1994) Sequencing of chromosome I of Saccharomyces cerevisiae: analysis of the 42 kbp SPO7-CENI-CDC15 region. Yeast 10(4):535-41
3) Lefebvre O, et al.  (1994) A mutation in the largest subunit of yeast TFIIIC affects tRNA and 5 S RNA synthesis. Identification of two classes of suppressors. J Biol Chem 269(37):23374-81
4) Harris SD and Pringle JR  (1991) Genetic analysis of Saccharomyces cerevisiae chromosome I: on the role of mutagen specificity in delimiting the set of genes identifiable using temperature-sensitive-lethal mutations. Genetics 127(2):279-85
5) Conesa C, et al.  (1993) On the subunit composition, stoichiometry, and phosphorylation of the yeast transcription factor TFIIIC/tau. J Biol Chem 268(24):18047-52
6) Geiduschek EP and Kassavetis GA  (2001) The RNA polymerase III transcription apparatus. J Mol Biol 310(1):1-26
7) Schultz P, et al.  (1989) The two DNA-binding domains of yeast transcription factor tau as observed by scanning transmission electron microscopy. EMBO J 8(12):3815-24