Standard Name	TFC3 1
Systematic Name	YAL001C
Alias	FUN24 2 , TSV115 3 , 4
Feature Type	ORF, Verified
Description	Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding (1, 5, 6, 7)
Name Description	Transcription Factor class C 1
Gene Product Alias	tau 138 1

Chromosomal Location	ChrI:151166 to 147594 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: -1 cM

	View Computational GO annotations for TFC3
Molecular Function
Manually curated	contributes_to DNA binding, bending (IDA) contributes_to RNA polymerase III type 1 promoter sequence-specific DNA binding (IDA) contributes_to RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity (IDA) contributes_to RNA polymerase III type 2 promoter sequence-specific DNA binding (IDA) contributes_to RNA polymerase III type 2 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity (IDA)
Biological Process
Manually curated	5S class rRNA transcription from RNA polymerase III type 1 promoter (IDA, IMP) protein localization to chromatin (IMP) transcription from a RNA polymerase III hybrid type promoter (IDA) transcription from RNA polymerase III type 2 promoter (IDA)
Cellular Component
Manually curated	colocalizes_with nuclear condensin complex (IDA) transcription factor TFIIIC complex (IDA)
High-throughput	mitochondrion (IDA)

Classical genetics
conditional	Brn1p distribution: abnormal Scc4p distribution: abnormal
null	inviable
Large-scale survey
null	competitive fitness: decreased filamentous growth: increased haploinsufficient heat sensitivity: increased invasive growth: absent inviable
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	58 total interaction(s) for 36 unique genes/features.
Physical Interactions	Affinity Capture-MS: 26 Affinity Capture-Western: 11 Co-fractionation: 1 Far Western: 1
Genetic Interactions	Dosage Rescue: 16 Synthetic Lethality: 1 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrI:151166 to 147594 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: -1 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..70 151166..151097 2011-02-03 1996-07-31 Intron 71..160 151096..151007 2011-02-03 1996-07-31 CDS 161..3573 151006..147594 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS) Intron (71 - 160)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000001