YAF9/YNL107W Summary Help

Standard Name YAF9 1
Systematic Name YNL107W
Feature Type ORF, Verified
Description Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes; may function to antagonize silencing near telomeres; interacts directly with Swc4p; has homology to human leukemogenic protein AF9; contains a YEATS domain (2, 3)
Name Description Yeast homolog of the human leukemogenic protein AF9 3
Chromosomal Location
ChrXIV:420098 to 420778 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All YAF9 GO evidence and references
  View Computational GO annotations for YAF9
Molecular Function
Manually curated
Biological Process
Manually curated
High-throughput
Cellular Component
Manually curated
High-throughput
Regulators 5 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
699 total interaction(s) for 381 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 90
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 36
  • Co-crystal Structure: 2
  • Co-purification: 1
  • Two-hybrid: 58

Genetic Interactions
  • Dosage Growth Defect: 11
  • Dosage Rescue: 2
  • Negative Genetic: 231
  • Phenotypic Enhancement: 8
  • Phenotypic Suppression: 1
  • Positive Genetic: 37
  • Synthetic Growth Defect: 155
  • Synthetic Lethality: 56
  • Synthetic Rescue: 9

Resources
Expression Summary
histogram
Resources
Length (a.a.) 226
Molecular Weight (Da) 25,981
Isoelectric Point (pI) 5.16
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:420098 to 420778 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..681 420098..420778 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005051
References cited on this page View Complete Literature Guide for YAF9
1) Birrell GW, et al.  (2001) A genome-wide screen in Saccharomyces cerevisiae for genes affecting UV radiation sensitivity. Proc Natl Acad Sci U S A 98(22):12608-13
2) Bittner CB, et al.  (2004) Direct physical and functional interaction of the NuA4 complex components Yaf9p and Swc4p. Eukaryot Cell 3(4):976-83
3) Zhang H, et al.  (2004) The Yaf9 component of the SWR1 and NuA4 complexes is required for proper gene expression, histone H4 acetylation, and Htz1 replacement near telomeres. Mol Cell Biol 24(21):9424-36