XPT1/YJR133W Summary Help

Standard Name XPT1 1
Systematic Name YJR133W
Feature Type ORF, Verified
Description Xanthine-guanine phosphoribosyl transferase; required for xanthine utilization and for optimal utilization of guanine (1 and see Summary Paragraph)
Name Description Xanthine Phosphoribosyl Transferase 1
Chromosomal Location
ChrX:672991 to 673620 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All XPT1 GO evidence and references
  View Computational GO annotations for XPT1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 5 genes
Resources
Pathways
Large-scale survey
null
unspecified
Resources
27 total interaction(s) for 27 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 4
  • PCA: 1
  • Two-hybrid: 1

Genetic Interactions
  • Negative Genetic: 18
  • Positive Genetic: 1
  • Synthetic Growth Defect: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 209
Molecular Weight (Da) 23,671
Isoelectric Point (pI) 6.17
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrX:672991 to 673620 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..630 672991..673620 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003894
SUMMARY PARAGRAPH for XPT1

XPT1 encodes xanthine phosphoribosyltransferase, an enzyme involved in the salvage pathway of purine nucleotide biosynthesis. Xpt1p catalyzes the conversion of 5-phospho-ribosyl-pyrophosphate plus the purine base xanthine to XMP (1). Xpt1p is 56% identical to the hypoxanthine-guanine phosphoribosyltransferase Hpt1p and overexpression of XPT1 partially rescues cells lacking Hpt1p activity, suggesting that Xpt1p can also use hypoxanthine as a substrate. In xpt1 null mutants, if the de novo pathway of guanine nucleotide biosynthesis is blocked, either through mutation of ade2 or by the addition of mycophenolic acid, cells are unable to grow even with the addition of xanthine to the media (1).

Last updated: 2006-09-18 Contact SGD

References cited on this page View Complete Literature Guide for XPT1
1) Guetsova ML, et al.  (1999) Isolation and characterization of the Saccharomyces cerevisiae XPT1 gene encoding xanthine phosphoribosyl transferase. J Bacteriol 181(9):2984-6