Standard Name	XBP1
Systematic Name	YIL101C
Feature Type	ORF, Verified
Description	Transcriptional repressor; binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress (1, 2, 3, 4)
Name Description	XhoI site-Binding Protein 2

Chromosomal Location	ChrIX:177250 to 175307 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for XBP1
Molecular Function
Manually curated	sequence-specific DNA binding transcription factor activity (IDA)
High-throughput	sequence-specific DNA binding (IDA)
Biological Process
Manually curated	response to stress (IDA, IMP)
Cellular Component
Manually curated	nucleus (IDA, IPI)
High-throughput	cytoplasm (IDA) nucleus (IDA)

Binding motifs	Predicted XBP1 Binding Site Locations
	GCCTCGARGMGR 2 [Search intergenic regions for GCCTCGARGMGR] YTCGAR 5, 6 [Search intergenic regions for YTCGAR]
Regulatory modules	predicted: stressResponse (619, 613, 565, 535, 505, 481)
Resources	ScerTF | UniProbe | YEASTRACT | YeTFaSCo

Classical genetics
null	cell size: normal cellular morphology: normal hyperosmotic stress resistance: normal vegetative growth: normal viable
overexpression	budding index: abnormal cell cycle progression in G1 phase: increased duration cell cycle progression in G1 phase: abnormal cell size: increased cellular morphology: abnormal vegetative growth: decreased
Large-scale survey
null	competitive fitness: decreased resistance to BPS: increased resistance to benzo[a]pyrene: decreased vegetative growth: abnormal viable
overexpression	vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	33 total interaction(s) for 29 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-RNA: 4 Affinity Capture-Western: 4 Biochemical Activity: 2 Co-localization: 1 Protein-RNA: 1
Genetic Interactions	Negative Genetic: 12 Phenotypic Enhancement: 1 Positive Genetic: 1 Synthetic Growth Defect: 2 Synthetic Haploinsufficiency: 1 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIX:177250 to 175307 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1994-12-10
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1944 177250..175307 2011-02-03 1994-12-10
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001363