WSC4/YHL028W Summary Help

Standard Name WSC4 1
Systematic Name YHL028W
Alias YHC8 2 , YFW1 3
Feature Type ORF, Verified
Description Endoplasmic reticulum (ER) membrane protein; involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3 (4, 5)
Name Description cell Wall integrity and Stress response Component 1
Chromosomal Location
ChrVIII:48763 to 50580 | ORF Map | GBrowse
Gene Ontology Annotations All WSC4 GO evidence and references
  View Computational GO annotations for WSC4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 11 genes
Classical genetics
Large-scale survey
21 total interaction(s) for 18 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 1

Genetic Interactions
  • Negative Genetic: 11
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 1
  • Positive Genetic: 3
  • Synthetic Lethality: 2
  • Synthetic Rescue: 1

Expression Summary
Length (a.a.) 605
Molecular Weight (Da) 63,807
Isoelectric Point (pI) 6.57
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrVIII:48763 to 50580 | ORF Map | GBrowse
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..1818 48763..50580 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001020
References cited on this page View Complete Literature Guide for WSC4
1) Verna J, et al.  (1997) A family of genes required for maintenance of cell wall integrity and for the stress response in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 94(25):13804-9
2) Mamoun CB, et al.  (1996) The TSR1 gene of Yarrowia lipolytica is involved in the signal recognition particle-dependent translocation pathway of secretory proteins. J Biol Chem 271(39):23895-901
3) Wei YF, et al.  (1995) Suppression of Escherichia coli alkB mutants by Saccharomyces cerevisiae genes. J Bacteriol 177(17):5009-15
4) Mamoun CB, et al.  (1999) Disruption of YHC8, a member of the TSR1 gene family, reveals its direct involvement in yeast protein translocation. J Biol Chem 274(16):11296-302
5) Zu T, et al.  (2001) Mutations in WSC genes for putative stress receptors result in sensitivity to multiple stress conditions and impairment of Rlm1-dependent gene expression in Saccharomyces cerevisiae. Mol Genet Genomics 266(1):142-55