WSC2/YNL283C Summary Help

Standard Name WSC2 1
Systematic Name YNL283C
Alias STA3
Feature Type ORF, Verified
Description Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway; involved in maintenance of cell wall integrity and recovery from heat shock; required for the arrest of secretion response; WSC2 has a paralog, WSC3, that arose from the whole genome duplication (1, 2, 3, 4, 5, 6, 7, 8)
Name Description cell Wall integrity and Stress response Component 1
Chromosomal Location
ChrXIV:106695 to 105184 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All WSC2 GO evidence and references
  View Computational GO annotations for WSC2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 4 genes
Classical genetics
Large-scale survey
58 total interaction(s) for 48 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 3
  • PCA: 18

Genetic Interactions
  • Dosage Rescue: 20
  • Negative Genetic: 4
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 5
  • Synthetic Growth Defect: 2
  • Synthetic Rescue: 3

Expression Summary
Length (a.a.) 503
Molecular Weight (Da) 52,292
Isoelectric Point (pI) 6.95
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrXIV:106695 to 105184 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2005-11-07 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..1512 106695..105184 2005-11-07 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005227
References cited on this page View Complete Literature Guide for WSC2
1) Verna J, et al.  (1997) A family of genes required for maintenance of cell wall integrity and for the stress response in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 94(25):13804-9
2) Raboy B, et al.  (1999) Heat-induced cell cycle arrest of Saccharomyces cerevisiae: involvement of the RAD6/UBC2 and WSC2 genes in its reversal. Mol Microbiol 32(4):729-39
3) Kosodo Y, et al.  (2001) Multicopy suppressors of the sly1 temperature-sensitive mutation in the ER-Golgi vesicular transport in Saccharomyces cerevisiae. Yeast 18(11):1003-14
4) Zu T, et al.  (2001) Mutations in WSC genes for putative stress receptors result in sensitivity to multiple stress conditions and impairment of Rlm1-dependent gene expression in Saccharomyces cerevisiae. Mol Genet Genomics 266(1):142-55
5) Nanduri J and Tartakoff AM  (2001) The arrest of secretion response in yeast: signaling from the secretory path to the nucleus via Wsc proteins and Pkc1p. Mol Cell 8(2):281-9
6) Ng DT  (2001) Interorganellar signal transduction: the arrest of secretion response. Dev Cell 1(3):319-20
7) Imazu H and Sakurai H  (2005) Saccharomyces cerevisiae heat shock transcription factor regulates cell wall remodeling in response to heat shock. Eukaryot Cell 4(6):1050-6
8) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61