Standard Name	VTS1 1
Systematic Name	YOR359W
Feature Type	ORF, Verified
Description	Flap-structured DNA-binding and RNA-binding protein; stimulates deadenylation-dependent mRNA degradation mediated by the CCR4-NOT deadenylase complex; member of the Smaug (Smg) family of post-transcriptional regulators which bind RNA through a conserved sterile alpha motif (SAM) domain that interacts with Smg recognition element (SREs) containing transcripts; stimulates Dna2p endonuclease activity (2, 3, 4, 5)
Name Description	VTi1-2 Suppressor 1

Chromosomal Location	ChrXV:1011189 to 1012760 | ORF Map | GBrowse

	View Computational GO annotations for VTS1
Molecular Function
Manually curated	flap-structured DNA binding (IDA) RNA binding (IDA)
Biological Process
Manually curated	nuclear-transcribed mRNA catabolic process (IMP) nuclear-transcribed mRNA poly(A) tail shortening (IMP, IPI) positive regulation of endodeoxyribonuclease activity (IDA, IPI)
Cellular Component
Manually curated	cytoplasmic mRNA processing body (IDA) cytosol (IDA) nucleus (IDA)

Classical genetics
null	tellurium atom accumulation: increased viable
Large-scale survey
null	anaerobic growth: decreased auxotrophy competitive fitness: decreased heat sensitivity: increased Fus-Mid-GFP distribution: abnormal resistance to trichothecene: increased resistance to amitrole: decreased resistance to cycloheximide: decreased resistance to nickel sulfate: increased resistance to quinine: increased resistance to arsenite(3-): decreased resistance to tunicamycin: decreased resistance to L-canavanine: increased resistance to streptomycin: decreased resistance to doxorubicin: decreased resistance to benzo[a]pyrene: decreased sporulation efficiency: increased toxin resistance: decreased vacuolar morphology: abnormal vegetative growth: decreased rate viable
overexpression	filamentous growth: decreased invasive growth: absent vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	31 total interaction(s) for 31 unique genes/features.
Physical Interactions	Affinity Capture-MS: 5 Affinity Capture-RNA: 1 Affinity Capture-Western: 3 Biochemical Activity: 1 Protein-RNA: 1 Two-hybrid: 4
Genetic Interactions	Dosage Rescue: 2 Negative Genetic: 8 Positive Genetic: 3 Synthetic Growth Defect: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:1011189 to 1012760 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1572 1011189..1012760 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005886