Standard Name	VTC1 1
Systematic Name	YER072W
Alias	NRF1 2 , PHM4 3
Feature Type	ORF, Verified
Description	Subunit of the vacuolar transporter chaperone (VTC) complex; VTC complex is involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; also has mRNA binding activity; protein abundance increases in response to DNA replication stress (1, 3, 4, 5, 6, 7, 8, 9)
Name Description	Vacuolar Transporter Chaperone 1

Chromosomal Location	ChrV:302806 to 303195 | ORF Map | GBrowse

	View Computational GO annotations for VTC1
Molecular Function
Manually curated	mRNA binding (IDA)
Biological Process
Manually curated	microautophagy (IDA, IMP) polyphosphate metabolic process (IMP) vacuolar transport (IDA, IMP) vacuole fusion, non-autophagic (IMP)
Cellular Component
Manually curated	endoplasmic reticulum (IDA) intrinsic to vacuolar membrane (IDA) vacuolar transporter chaperone complex (IPI)
High-throughput	integral to membrane (ISM)

Classical genetics
null	polyphosphate accumulation: absent polyphosphate accumulation: decreased metal resistance: increased metal resistance: decreased small molecule transport: decreased rate
Large-scale survey
null	anaerobic growth: decreased cell cycle progression in G1 phase: increased duration polyphosphate accumulation: abnormal competitive fitness: decreased dessication resistance: decreased metal resistance: increased resistance to nickel sulfate: increased stress resistance: decreased vegetative growth: decreased rate vegetative growth: abnormal
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	102 total interaction(s) for 88 unique genes/features.
Physical Interactions	Affinity Capture-MS: 8 Affinity Capture-RNA: 5 Affinity Capture-Western: 1 Biochemical Activity: 3
Genetic Interactions	Negative Genetic: 68 Phenotypic Enhancement: 1 Phenotypic Suppression: 2 Positive Genetic: 7 Synthetic Growth Defect: 5 Synthetic Lethality: 1 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrV:302806 to 303195 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..390 302806..303195 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000874