VTA1/YLR181C Summary Help

Standard Name VTA1 1
Systematic Name YLR181C
Feature Type ORF, Verified
Description Multivesicular body (MVB) protein; involved in endosomal protein sorting; regulates Vps4p activity by promoting its oligomerization; has an N-terminal Vps60- and Did2- binding domain, a linker region, and a C-terminal Vps4p binding domain (2, 3, 4, 5, 6)
Name Description VpsTwenty Associated 1
Chromosomal Location
ChrXII:517670 to 516678 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All VTA1 GO evidence and references
  View Computational GO annotations for VTA1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Classical genetics
null
reduction of function
Large-scale survey
null
Resources
94 total interaction(s) for 51 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 10
  • Co-crystal Structure: 4
  • Co-purification: 2
  • PCA: 4
  • Reconstituted Complex: 13
  • Two-hybrid: 16

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Rescue: 1
  • Negative Genetic: 23
  • Phenotypic Enhancement: 7
  • Positive Genetic: 4
  • Synthetic Growth Defect: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 330
Molecular Weight (Da) 37,315
Isoelectric Point (pI) 4.33
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:517670 to 516678 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..993 517670..516678 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004171
References cited on this page View Complete Literature Guide for VTA1
1) Eguez,L and Garrett, S  (2003) Membrane and Protein Interaction Requirements of Class E Vps Proteins
2) Yeo SC, et al.  (2003) Vps20p and Vta1p interact with Vps4p and function in multivesicular body sorting and endosomal transport in Saccharomyces cerevisiae. J Cell Sci 116(Pt 19):3957-70
3) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
4) Shiflett SL, et al.  (2004) Characterization of Vta1p, a class E Vps protein in Saccharomyces cerevisiae. J Biol Chem 279(12):10982-90
5) Azmi I, et al.  (2006) Recycling of ESCRTs by the AAA-ATPase Vps4 is regulated by a conserved VSL region in Vta1. J Cell Biol 172(5):705-17
6) Xiao J, et al.  (2008) Structural basis of vta1 function in the multivesicular body sorting pathway. Dev Cell 14(1):37-49