Standard Name	VPS75
Systematic Name	YNL246W
Feature Type	ORF, Verified
Description	NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair; protein abundance increases in response to DNA replication stress (1, 2, 3, 4, 5, 6, 7)
Name Description	Vacuolar Protein Sorting 1

Chromosomal Location	ChrXIV:185460 to 186349 | ORF Map | GBrowse

	View Computational GO annotations for VPS75
Molecular Function
Manually curated	acetyltransferase activator activity (IDA, IMP) histone binding (IDA, IPI)
Biological Process
Manually curated	double-strand break repair via nonhomologous end joining (IMP, IPI) nucleosome assembly (IDA) positive regulation of histone acetylation (IDA, IGI, IMP)
Cellular Component
Manually curated	colocalizes_with chromatin (IDA)
High-throughput	nucleus (IDA)

Classical genetics
null	UV resistance: decreased lithium(1+) accumulation: increased heat sensitivity: increased ionic stress resistance: decreased Rtt109-GFP2 distribution: abnormal resistance to hydroxyurea: normal resistance to acetic acid: increased resistance to hydroxyurea: decreased resistance to methyl methanesulfonate: decreased resistance to methotrexate: decreased resistance to sodium chloride: decreased vegetative growth: decreased
unspecified	Rtt109-GFP2 distribution: abnormal
Large-scale survey
null	bud morphology: abnormal rubidium(1+) accumulation: decreased competitive fitness: decreased dessication resistance: decreased heat sensitivity: increased inviable ionic stress resistance: decreased Hta1p-GFP accumulation: decreased resistance to sirolimus: increased resistance to wortmannin: increased resistance to nickel sulfate: increased resistance to cycloheximide: increased resistance to pyrrolidine dithiocarbamate: decreased resistance to fenpropimorph: decreased resistance to sodium selenide: decreased resistance to dimethyl sulfoxide: decreased resistance to arsenite(3-): decreased resistance to caffeine: decreased resistance to cycloheximide: decreased resistance to hygromycin B: decreased telomere length: decreased vacuolar morphology: abnormal vegetative growth: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	132 total interaction(s) for 96 unique genes/features.
Physical Interactions	Affinity Capture-MS: 12 Affinity Capture-RNA: 3 Affinity Capture-Western: 8 Biochemical Activity: 4 Co-crystal Structure: 8 Co-purification: 1 Reconstituted Complex: 19 Two-hybrid: 1
Genetic Interactions	Negative Genetic: 37 Phenotypic Enhancement: 3 Phenotypic Suppression: 4 Positive Genetic: 16 Synthetic Growth Defect: 15 Synthetic Haploinsufficiency: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:185460 to 186349 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..32 185460..185491 2011-02-03 1996-07-31 Intron 33..127 185492..185586 2011-02-03 1996-07-31 CDS 128..890 185587..186349 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS) Intron (33 - 127)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005190