Standard Name	VPS72
Systematic Name	YDR485C
Alias	SWC2
Feature Type	ORF, Verified
Description	Htz1p-binding component of the SWR1 complex; exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; may function as a lock that prevents removal of H2AZ from nucleosomes; required for vacuolar protein sorting (1, 2, 3)
Name Description	Vacuolar Protein Sorting 1

Chromosomal Location	ChrIV:1427207 to 1424820 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for VPS72
Molecular Function
Manually curated	histone binding (IPI)
Biological Process
Manually curated	chromatin remodeling (IDA, IMP) histone exchange (IMP)
High-throughput	chromatin remodeling (IGI)
Cellular Component
Manually curated	Swr1 complex (IDA)
High-throughput	cytoplasm (IDA) nucleus (IDA)

Classical genetics
null	viable
Large-scale survey
null	bud morphology: abnormal competitive fitness: decreased heat sensitivity: increased ionic stress resistance: decreased metal resistance: decreased mitotic recombination: increased protein transport: abnormal Rad52-YFP distribution: increased resistance to hygromycin B: decreased resistance to pyrrolidine dithiocarbamate: decreased resistance to 1,4-dithiothreitol and tacrolimus (anhydrous): increased resistance to tacrolimus (anhydrous) and tunicamycin: increased resistance to dimethyl sulfoxide: decreased resistance to flubendazole: decreased resistance to spermine: decreased resistance to sodium selenide: decreased resistance to cycloheximide: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	843 total interaction(s) for 349 unique genes/features.
Physical Interactions	Affinity Capture-MS: 40 Affinity Capture-RNA: 2 Affinity Capture-Western: 8 Reconstituted Complex: 1 Two-hybrid: 3
Genetic Interactions	Negative Genetic: 463 Phenotypic Enhancement: 41 Phenotypic Suppression: 12 Positive Genetic: 46 Synthetic Growth Defect: 106 Synthetic Lethality: 58 Synthetic Rescue: 63
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:1427207 to 1424820 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 2003-09-22
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2388 1427207..1424820 2011-02-03 2003-09-22
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002893