Standard Name	VPS71
Systematic Name	YML041C
Alias	SWC6
Feature Type	ORF, Verified
Description	Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting (1, 2)
Name Description	Vacuolar Protein Sorting 1

Chromosomal Location	ChrXIII:195755 to 194913 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for VPS71
Molecular Function
Manually curated	nucleosome binding (IMP)
Biological Process
Manually curated	chromatin remodeling (IDA, IMP) histone exchange (IMP)
High-throughput	chromatin remodeling (IGI) protein targeting to vacuole (IMP)
Cellular Component
Manually curated	Swr1 complex (IDA)
High-throughput	nucleus (IDA)

Classical genetics
null	replicative lifespan: decreased resistance to hydroxyurea: decreased resistance to 1,1'-azobis(N,N-dimethylformamide): decreased resistance to benomyl: decreased viable
Large-scale survey
null	bud morphology: abnormal competitive fitness: decreased heat sensitivity: increased hyperosmotic stress resistance: decreased ionic stress resistance: decreased metal resistance: decreased mitotic recombination: increased protein transport: abnormal Rad52-YFP distribution: increased resistance to dimethyl sulfoxide: decreased resistance to sodium selenide: decreased resistance to spermine: decreased resistance to hygromycin B: decreased resistance to oleate: decreased resistance to 1,4-dithiothreitol and tacrolimus (anhydrous): increased resistance to tacrolimus (anhydrous) and tunicamycin: increased resistance to doxorubicin: decreased resistance to mefloquine: decreased resistance to BPS: decreased resistance to flubendazole: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	915 total interaction(s) for 415 unique genes/features.
Physical Interactions	Affinity Capture-MS: 40 Affinity Capture-Western: 4 Two-hybrid: 3
Genetic Interactions	Negative Genetic: 577 Phenotypic Enhancement: 50 Phenotypic Suppression: 6 Positive Genetic: 67 Synthetic Growth Defect: 103 Synthetic Lethality: 59 Synthetic Rescue: 6
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:195755 to 194913 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..843 195755..194913 1996-07-31 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004505