VPS41/YDR080W Summary Help

Standard Name VPS41 1
Systematic Name YDR080W
Alias CVT8 , FET2 , SVL2 2 , VAM2 3 , VPL20 1
Feature Type ORF, Verified
Description Vacuolar membrane protein that is a subunit of the HOPS complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport; the homotypic vacuole fusion and vacuole protein sorting complex is also known as the HOPS complex (4, 5, 6)
Name Description Vacuolar Protein Sorting 1
Chromosomal Location
ChrIV:604008 to 606986 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All VPS41 GO evidence and references
  View Computational GO annotations for VPS41
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Classical genetics
null
reduction of function
unspecified
Large-scale survey
null
overexpression
repressible
Resources
377 total interaction(s) for 220 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 32
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 52
  • Biochemical Activity: 2
  • Co-fractionation: 2
  • Co-purification: 2
  • Reconstituted Complex: 13
  • Two-hybrid: 20

Genetic Interactions
  • Dosage Lethality: 1
  • Negative Genetic: 199
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 1
  • Positive Genetic: 29
  • Synthetic Growth Defect: 13
  • Synthetic Lethality: 8

Resources
Expression Summary
histogram
Resources
Length (a.a.) 992
Molecular Weight (Da) 113,411
Isoelectric Point (pI) 4.61
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:604008 to 606986 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2979 604008..606986 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002487
References cited on this page View Complete Literature Guide for VPS41
1) Raymond CK, et al.  (1992) Morphological classification of the yeast vacuolar protein sorting mutants: evidence for a prevacuolar compartment in class E vps mutants. Mol Biol Cell 3(12):1389-402
2) Zheng B, et al.  (1998) Isolation of yeast mutants defective for localization of vacuolar vital dyes. Proc Natl Acad Sci U S A 95(20):11721-6
3) Wada Y, et al.  (1992) Genes for directing vacuolar morphogenesis in Saccharomyces cerevisiae. I. Isolation and characterization of two classes of vam mutants. J Biol Chem 267(26):18665-70
4) Seals DF, et al.  (2000) A Ypt/Rab effector complex containing the Sec1 homolog Vps33p is required for homotypic vacuole fusion. Proc Natl Acad Sci U S A 97(17):9402-7
5) Cowles CR, et al.  (1997) Novel Golgi to vacuole delivery pathway in yeast: identification of a sorting determinant and required transport component. EMBO J 16(10):2769-82
6) Nakamura N, et al.  (1997) Vam2/Vps41p and Vam6/Vps39p are components of a protein complex on the vacuolar membranes and involved in the vacuolar assembly in the yeast Saccharomyces cerevisiae. J Biol Chem 272(17):11344-9