Standard Name	VPS38 1, 2
Systematic Name	YLR360W
Alias	VPL17 2
Feature Type	ORF, Verified
Description	Part of a Vps34p phosphatidylinositol 3-kinase complex that functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity; required for overflow degradation of misfolded proteins when ERAD is saturated (3, 4, 5)
Name Description	Vacuolar Protein Sorting 1, 2

Chromosomal Location	ChrXII:846103 to 847422 | ORF Map | GBrowse

	View Computational GO annotations for VPS38
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	late endosome to vacuole transport (IGI, IMP)
Cellular Component
Manually curated	phosphatidylinositol 3-kinase complex II (IDA)

Classical genetics
null	1-phosphatidyl-1D-myo-inositol 3-phosphate accumulation: decreased metal resistance: decreased A1PiZ accumulation: increased Vps5p-GFP distribution: abnormal Pep1p-HA distribution: abnormal Kex2p-GFP distribution: abnormal Vps17p-GFP distribution: abnormal vacuolar morphology: abnormal
reduction of function	vacuolar transport: abnormal
Large-scale survey
null	inositol excretion: increased glutathione excretion: increased competitive fitness: decreased haploinsufficient metal resistance: decreased Fus-Mid-GFP distribution: abnormal Cps1p (CPS) modification: decreased Pho8p (ALP) modification: decreased resistance to wortmannin: increased resistance to sodium selenide: decreased resistance to propolis extract: decreased resistance to nickel sulfate: increased resistance to nickel(2+): increased resistance to sirolimus: decreased resistance to ethanol: decreased resistance to calcium dichloride: decreased resistance to hygromycin B: decreased resistance to glycolaldehyde: decreased resistance to benzo[a]pyrene: decreased resistance to cycloheximide: decreased resistance to benzo[a]pyrene: increased resistance to dimethyl sulfoxide: decreased resistance to mefloquine: decreased starvation resistance: decreased stress resistance: decreased toxin resistance: decreased vacuolar morphology: abnormal vegetative growth: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	101 total interaction(s) for 81 unique genes/features.
Physical Interactions	Affinity Capture-MS: 8 Affinity Capture-Western: 5 PCA: 2
Genetic Interactions	Dosage Lethality: 1 Negative Genetic: 46 Phenotypic Enhancement: 8 Phenotypic Suppression: 8 Positive Genetic: 4 Synthetic Growth Defect: 11 Synthetic Lethality: 7 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:846103 to 847422 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1320 846103..847422 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004352