Standard Name	VPS17 1, 2
Systematic Name	YOR132W
Alias	PEP21 , VPT3 3
Feature Type	ORF, Verified
Description	Subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde protein transport; peripheral membrane protein that assembles onto the membrane with Vps5p to promote vesicle formation; required for recruiting the retromer complex to the endosome membranes (4, 5, 6, 7)
Name Description	Vacuolar Protein Sorting 1, 2

Chromosomal Location	ChrXV:573175 to 574830 | ORF Map | GBrowse

	View Computational GO annotations for VPS17
Molecular Function
Manually curated	phosphatidylinositol-3-phosphate binding (IDA) contributes_to protein transporter activity (IMP, IPI)
Biological Process
Manually curated	retrograde transport, endosome to Golgi (IPI)
Cellular Component
Manually curated	endosome (IPI) retromer complex (IMP, IPI) retromer complex, outer shell (IPI)

Classical genetics
reduction of function	vacuolar morphology: abnormal vacuolar transport: abnormal
Large-scale survey
null	glutathione excretion: increased inositol excretion: increased chitin deposition: normal competitive fitness: decreased Cps1p (CPS) modification: decreased Pho8p (ALP) modification: decreased resistance to caffeine: decreased resistance to hydrogen chloride: decreased resistance to neothyonidioside: decreased resistance to sodium selenide: decreased resistance to nickel sulfate: increased resistance to L-1,4-dithiothreitol: decreased stress resistance: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	211 total interaction(s) for 132 unique genes/features.
Physical Interactions	Affinity Capture-MS: 13 Affinity Capture-RNA: 1 Affinity Capture-Western: 10 Co-fractionation: 1 Co-purification: 1 PCA: 5 Reconstituted Complex: 5 Two-hybrid: 9
Genetic Interactions	Dosage Lethality: 1 Negative Genetic: 117 Phenotypic Enhancement: 1 Phenotypic Suppression: 2 Positive Genetic: 21 Synthetic Growth Defect: 15 Synthetic Lethality: 9
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:573175 to 574830 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1656 573175..574830 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005658