Standard Name	VMS1 1
Systematic Name	YDR049W
Feature Type	ORF, Verified
Description	Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans (1, 2, 3)
Name Description	VCP/Cdc48-associated Mitochondrial Stress-responsive 1

Chromosomal Location	ChrIV:553254 to 555152 | ORF Map | GBrowse

	View Computational GO annotations for VMS1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	ER-associated protein catabolic process (IMP) mitochondria-associated protein catabolic process (IMP) nucleus-associated proteasomal ubiquitin-dependent protein catabolic process (IMP)
Cellular Component
Manually curated	Cdc48p-Npl4p-Vms1p AAA ATPase complex (IDA) cytosol (IDA) endoplasmic reticulum membrane (IDA) mitochondrion (IDA)
High-throughput	cytoplasm (IDA) mitochondrion (IDA)

Resources	YeTFaSCo

Classical genetics
null	mitophagy: increased oxidative stress resistance: decreased Fzo1p accumulation: increased Cdc48p distribution: abnormal resistance to mycophenolic acid: decreased resistance to sirolimus: decreased respiratory growth: decreased survival rate in stationary phase: decreased
Large-scale survey
null	auxotrophy bud morphology: abnormal competitive fitness: decreased Fus-Mid-GFP distribution: abnormal resistance to nickel(2+): decreased resistance to sirolimus: decreased resistance to nickel sulfate: increased resistance to cycloheximide: decreased resistance to mycophenolic acid: decreased resistance to acetaldehyde: decreased resistance to CTBT: decreased resistance to tunicamycin: decreased resistance to 1,4-dithiothreitol: decreased resistance to 2-phenyl-3-nitroso-imidazo[1,2-a]pyrimidine: decreased resistance to BPS: decreased resistance to wortmannin: increased resistance to caffeine: decreased resistance to hygromycin B: decreased resistance to doxorubicin: decreased stress resistance: increased toxin resistance: decreased utilization of carbon source: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	219 total interaction(s) for 180 unique genes/features.
Physical Interactions	Affinity Capture-MS: 9 Affinity Capture-RNA: 1 Affinity Capture-Western: 13 Reconstituted Complex: 1
Genetic Interactions	Dosage Rescue: 2 Negative Genetic: 150 Phenotypic Enhancement: 13 Phenotypic Suppression: 1 Positive Genetic: 14 Synthetic Growth Defect: 11 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:553254 to 555152 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1899 553254..555152 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002456