VMA21/YGR105W Summary Help

Standard Name VMA21
Systematic Name YGR105W
Feature Type ORF, Verified
Description Integral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER) (1, 2, 3, 4)
Chromosomal Location
ChrVII:698599 to 698832 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All VMA21 GO evidence and references
  View Computational GO annotations for VMA21
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant phenotypes All VMA21 Phenotype evidence and references
Classical genetics
null
Large-scale survey
null
Resources
interactions All VMA21 Interaction evidence and references
658 total interaction(s) for 583 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 16
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 6
  • PCA: 11
Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 80
  • Phenotypic Enhancement: 3
  • Positive Genetic: 31
  • Synthetic Growth Defect: 504
  • Synthetic Lethality: 4
Resources
Expression Summary
histogram
Resources
Protein Information All VMA21 Protein evidence and references
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:698599 to 698832 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..234 698599..698832 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003337
References cited on this page View Complete Literature Guide for VMA21
1) Hill KJ and Stevens TH  (1994) Vma21p is a yeast membrane protein retained in the endoplasmic reticulum by a di-lysine motif and is required for the assembly of the vacuolar H(+)-ATPase complex. Mol Biol Cell 5(9):1039-50
2) Hirata R, et al.  (1993) VMA12 is essential for assembly of the vacuolar H(+)-ATPase subunits onto the vacuolar membrane in Saccharomyces cerevisiae. J Biol Chem 268(2):961-7
3) Graham LA and Stevens TH  (1999) Assembly of the yeast vacuolar proton-translocating ATPase. J Bioenerg Biomembr 31(1):39-47
4) Stevens TH and Forgac M  (1997) Structure, function and regulation of the vacuolar (H+)-ATPase. Annu Rev Cell Dev Biol 13:779-808