Standard Name	VIK1
Systematic Name	YPL253C
Feature Type	ORF, Verified
Description	Protein that forms a complex with Kar3p at the spindle pole body; possible regulator of Kar3p function in microtubule-mediated processes; required for sister chromatid cohesion; VIK1 has a paralog, CIK1, that arose from the whole genome duplication (1, 2, 3)
Name Description	Vegetative Interaction with Kar3p 1

Chromosomal Location	ChrXVI:73006 to 71063 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for VIK1
Molecular Function
Manually curated	microtubule motor activity (ISS)
Biological Process
Manually curated	microtubule-based process (IMP, IPI) mitotic sister chromatid cohesion (IGI, IMP)
Cellular Component
Manually curated	kinesin complex (IDA) spindle pole body (IDA)

Classical genetics
null	chromosome/plasmid maintenance: abnormal resistance to bortezomib: decreased
Large-scale survey
null	competitive fitness: decreased dessication resistance: decreased haploinsufficient heat sensitivity: increased Fus-Mid-GFP distribution: abnormal resistance to amitrole: decreased resistance to cycloheximide: decreased resistance to bleomycin: increased resistance to fenpropimorph: increased resistance to camptothecin: decreased resistance to cycloheximide: increased stress resistance: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	104 total interaction(s) for 59 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Affinity Capture-RNA: 1 Affinity Capture-Western: 1 Co-crystal Structure: 3 Reconstituted Complex: 3 Two-hybrid: 2
Genetic Interactions	Negative Genetic: 70 Positive Genetic: 2 Synthetic Growth Defect: 10 Synthetic Lethality: 10 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:73006 to 71063 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1944 73006..71063 1996-07-31 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000006174