Standard Name	VHR1 1
Systematic Name	YIL056W
Feature Type	ORF, Verified
Description	Transcriptional activator; required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations; VHR1 has a paralog, VHR2, that arose from the whole genome duplication (1, 2)
Name Description	VHt1 Regulator 1

Chromosomal Location	ChrIX:249991 to 251913 | ORF Map | GBrowse

	View Computational GO annotations for VHR1
Molecular Function
Manually curated	RNA polymerase II regulatory region sequence-specific DNA binding (IDA) sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity (IDA, IMP)
Biological Process
Manually curated	positive regulation of transcription from RNA polymerase II promoter (IMP) regulation of transcription from RNA polymerase II promoter in response to biotin starvation (IMP)
Cellular Component
Manually curated	nucleus (IDA)
High-throughput	cytoplasm (IDA) nucleus (IDA)

Resources	YEASTRACT | YeTFaSCo

Large-scale survey
null	competitive fitness: increased resistance to glycolaldehyde: decreased vacuolar morphology: abnormal
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	13 total interaction(s) for 13 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Affinity Capture-RNA: 1 Protein-RNA: 1 Two-hybrid: 1
Genetic Interactions	Negative Genetic: 7
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIX:249991 to 251913 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1994-12-10
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1923 249991..251913 2011-02-03 1994-12-10
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001318