VAR1/Q0140 Summary Help

Standard Name VAR1
Systematic Name Q0140
Feature Type ORF, Verified
Description Mitochondrial ribosomal protein of the small subunit; mitochondrially-encoded; polymorphic in different strains due to variation in number of AAT (asparagine) codons; translated near the mitochondrial inner membrane; may have a role in loss of mitochondrial DNA under stress conditions (1, 2, 3, 4, 5)
Also known as: VARI
Chromosomal Location
ChrMito:48901 to 50097 | ORF Map | GBrowse
Gene Ontology Annotations All VAR1 GO evidence and references
  View Computational GO annotations for VAR1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
12 total interaction(s) for 12 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 6
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 4

Genetic Interactions
  • Synthetic Rescue: 1

Expression Summary
Length (a.a.) 398
Molecular Weight (Da) 47,123
Isoelectric Point (pI) 10.75
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrMito:48901 to 50097 | ORF Map | GBrowse
Last Update Coordinates: 2000-05-19 | Sequence: 2000-05-19
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..1197 48901..50097 2000-05-19 2000-05-19
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000007275
References cited on this page View Complete Literature Guide for VAR1
1) Groot GS, et al.  (1979) Var1 is associated with the small ribosomal subunit of mitochondrial ribosomes in yeast. Mol Gen Genet 174(3):339-42
2) Hudspeth ME, et al.  (1982) Location and structure of the var1 gene on yeast mitochondrial DNA: nucleotide sequence of the 40.0 allele. Cell 30(2):617-26
3) Hudspeth ME, et al.  (1984) Expandable var1 gene of yeast mitochondrial DNA: in-frame insertions can explain the strain-specific protein size polymorphisms. Proc Natl Acad Sci U S A 81(10):3148-52
4) Fiori A, et al.  (2003) Evidence that synthesis of the Saccharomyces cerevisiae mitochondrially encoded ribosomal protein Var1p may be membrane localized. Eukaryot Cell 2(3):651-3
5) Litvinchuk AV, et al.  (2013) Mitochondrially-encoded protein Var1 promotes loss of respiratory function in Saccharomyces cerevisiae under stressful conditions. Eur J Cell Biol 92(4-5):169-74