Standard Name	VAN1 1
Systematic Name	YML115C
Alias	VRG7 , VRG8 , LDB13
Feature Type	ORF, Verified
Description	Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant (2, 3)
Name Description	VANadate resistance protein 1

Chromosomal Location	ChrXIII:41794 to 40187 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 38 cM

	View Computational GO annotations for VAN1
Molecular Function
Manually curated	contributes_to alpha-1,6-mannosyltransferase activity (IDA)
Biological Process
Manually curated	protein N-linked glycosylation (IDA, IMP)
Cellular Component
Manually curated	alpha-1,6-mannosyltransferase complex (IDA, IPI)

Classical genetics
null	survival rate in stationary phase: decreased
unspecified	heat sensitivity: increased Suc2p modification: decreased resistance to hygromycin B: decreased resistance to sodium orthovanadate: increased resistance to enzymatic treatment: decreased survival rate in stationary phase: decreased
Large-scale survey
null	auxotrophy chitin deposition: increased competitive fitness: decreased dessication resistance: decreased heat sensitivity: increased protein transport: abnormal resistance to neothyonidioside: decreased resistance to sodium arsenite: decreased resistance to acetic acid: decreased resistance to hygromycin B: decreased resistance to 5-fluorouracil: decreased resistance to Calcofluor White: decreased resistance to sirolimus: decreased resistance to caffeine: decreased resistance to cycloheximide: decreased resistance to tunicamycin: decreased resistance to 1,4-dithiothreitol: decreased resistance to wortmannin: normal resistance to lovastatin: decreased resistance to calcium dichloride: decreased resistance to doxorubicin: decreased sporulation efficiency: increased stress resistance: decreased toxin resistance: decreased vacuolar morphology: abnormal vegetative growth: decreased rate viable
overexpression	vegetative growth: decreased rate
unspecified	resistance to Calcofluor White: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	57 total interaction(s) for 35 unique genes/features.
Physical Interactions	Affinity Capture-MS: 6 Affinity Capture-RNA: 2 Affinity Capture-Western: 7 Co-fractionation: 2 Co-purification: 2 Reconstituted Complex: 1 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 3 Synthetic Growth Defect: 10 Synthetic Lethality: 23
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:41794 to 40187 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 38 cM
Last Update	Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1608 41794..40187 1996-07-31 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004583