Standard Name	VAC7 1
Systematic Name	YNL054W
Feature Type	ORF, Verified
Description	Integral vacuolar membrane protein involved in vacuole inheritance and morphology; activates Fab1p kinase activity under basal conditions and also after hyperosmotic shock (1, 2, 3)
Name Description	VACuolar segregation

Chromosomal Location	ChrXIV:526086 to 529583 | ORF Map | GBrowse

	View Computational GO annotations for VAC7
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	positive regulation of kinase activity (IGI) positive regulation of phosphatidylinositol biosynthetic process (IGI)
Cellular Component
Manually curated	fungal-type vacuole membrane (IDA) integral to membrane (IDA) PAS complex (IDA, IPI) vacuolar membrane (IDA)
High-throughput	cytoplasm (IDA)

Classical genetics
misexpression	vacuolar morphology: abnormal
null	heat sensitivity: increased oxidative stress resistance: decreased Atg18p-GFP distribution: abnormal resistance to monensin: decreased vacuolar morphology: abnormal
Large-scale survey
null	budding pattern: abnormal cell size: increased competitive fitness: decreased dessication resistance: decreased fermentative growth: decreased rate freeze-thaw resistance: decreased heat sensitivity: increased resistance to ethylenediaminetetraacetic acid: decreased resistance to Azaserine: decreased resistance to benomyl: decreased resistance to cycloheximide: decreased resistance to Calcofluor White: decreased resistance to caffeine: decreased resistance to sodium arsenite: decreased resistance to sodium selenide: decreased resistance to copper(2+) sulfate: decreased resistance to glycolaldehyde: decreased sporulation efficiency: decreased stress resistance: increased vacuolar morphology: abnormal vegetative growth: decreased viable
overexpression	filamentous growth: decreased invasive growth: absent vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	42 total interaction(s) for 40 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Affinity Capture-RNA: 2 Affinity Capture-Western: 1 Biochemical Activity: 1 PCA: 1 Two-hybrid: 2
Genetic Interactions	Negative Genetic: 1 Positive Genetic: 2 Synthetic Growth Defect: 22 Synthetic Lethality: 4 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:526086 to 529583 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..3498 526086..529583 2011-02-03 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004999