UBC6/YER100W Summary Help

Standard Name UBC6 1
Systematic Name YER100W
Alias DOA2 1 , 2
Feature Type ORF, Verified
Description Ubiquitin-conjugating enzyme involved in ERAD; located at the cytosolic side of the ER membrane; tail region contains a transmembrane segment at the C-terminus; substrate of the ubiquitin-proteasome pathway; ER-associated protein degradation is also known as ERAD (3, 4, 5, 6)
Name Description UBiquitin-Conjugating 3
Chromosomal Location
ChrV:359562 to 360314 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All UBC6 GO evidence and references
  View Computational GO annotations for UBC6
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 8 genes
Resources
Classical genetics
null
Resources
122 total interaction(s) for 88 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 17
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
  • Biochemical Activity: 2
  • PCA: 2
  • Protein-peptide: 1
  • Reconstituted Complex: 3
  • Two-hybrid: 4

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 54
  • Phenotypic Enhancement: 13
  • Phenotypic Suppression: 4
  • Positive Genetic: 11
  • Synthetic Growth Defect: 4
  • Synthetic Rescue: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 250
Molecular Weight (Da) 28,383
Isoelectric Point (pI) 6.08
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrV:359562 to 360314 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..753 359562..360314 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000902
References cited on this page View Complete Literature Guide for UBC6
1) Chen P, et al.  (1993) Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MAT alpha 2 repressor. Cell 74(2):357-69
2) Hochstrasser M and Varshavsky A  (1990) In vivo degradation of a transcriptional regulator: the yeast alpha 2 repressor. Cell 61(4):697-708
3) Sommer T and Jentsch S  (1993) A protein translocation defect linked to ubiquitin conjugation at the endoplasmic reticulum. Nature 365(6442):176-9
4) Gilon T, et al.  (2000) Degradation signals recognized by the Ubc6p-Ubc7p ubiquitin-conjugating enzyme pair. Mol Cell Biol 20(19):7214-9
5) Biederer T, et al.  (1996) Degradation of subunits of the Sec61p complex, an integral component of the ER membrane, by the ubiquitin-proteasome pathway. EMBO J 15(9):2069-76
6) Walter J, et al.  (2001) Sec61p-independent degradation of the tail-anchored ER membrane protein Ubc6p. EMBO J 20(12):3124-31