UTR2/YEL040W Summary Help

Standard Name UTR2 1
Systematic Name YEL040W
Alias CRH2 2
Feature Type ORF, Verified
Description Chitin transglycosylase; functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck (2, 3, 4, 5, 6)
Name Description Unidentified TRanscript 7
Chromosomal Location
ChrV:78053 to 79456 | ORF Map | GBrowse
Gene Ontology Annotations All UTR2 GO evidence and references
  View Computational GO annotations for UTR2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 12 genes
Classical genetics
Large-scale survey
82 total interaction(s) for 77 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 3
  • Co-fractionation: 2
  • PCA: 1
  • Protein-RNA: 1

Genetic Interactions
  • Negative Genetic: 57
  • Phenotypic Enhancement: 6
  • Positive Genetic: 1
  • Synthetic Growth Defect: 8
  • Synthetic Lethality: 1

Expression Summary
Length (a.a.) 467
Molecular Weight (Da) 49,906
Isoelectric Point (pI) 4.45
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrV:78053 to 79456 | ORF Map | GBrowse
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..1404 78053..79456 1996-07-31 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000766
References cited on this page View Complete Literature Guide for UTR2
1) Melnick L and Sherman F  (1993) The gene clusters ARC and COR on chromosomes 5 and 10, respectively, of Saccharomyces cerevisiae share a common ancestry. J Mol Biol 233(3):372-88
2) Rodriguez-Pena JM, et al.  (2000) A novel family of cell wall-related proteins regulated differently during the yeast life cycle. Mol Cell Biol 20(9):3245-55
3) Rodriguez-Pena JM, et al.  (2002) Mechanisms for targeting of the Saccharomyces cerevisiae GPI-anchored cell wall protein Crh2p to polarised growth sites. J Cell Sci 115(Pt 12):2549-58
4) Cabib E, et al.  (2007) Crh1p and Crh2p are required for the cross-linking of chitin to beta(1-6)glucan in the Saccharomyces cerevisiae cell wall. Mol Microbiol 63(3):921-35
5) Cabib E, et al.  (2008) Assembly of the Yeast Cell Wall: Crh1p AND Crh2p ACT AS TRANSGLYCOSYLASES IN VIVO AND IN VITRO. J Biol Chem 283(44):29859-72
6) Cabib E  (2009) Two novel techniques for determination of polysaccharide cross-links show that Crh1p and Crh2p attach chitin to both beta(1-6)- and beta(1-3)glucan in the Saccharomyces cerevisiae cell wall. Eukaryot Cell 8(11):1626-36
7) Barry K, et al.  (1987) Physical analysis of the COR region: a cluster of six genes in Saccharomyces cerevisiae. Mol Cell Biol 7(2):632-8