UTH1/YKR042W Summary Help

Standard Name UTH1 1
Systematic Name YKR042W
Feature Type ORF, Verified
Description Mitochondrial inner membrane protein; role in mitophagy is disputed; implicated in cell wall biogenesis, the oxidative stress response, life span during starvation, and cell death; SUN family member; UTH1 has a paralog, NCA3, that arose from the whole genome duplication (1, 2, 3, 4, 5, 6, 7, 8, 9)
Name Description yoUTH 1, 10
Chromosomal Location
ChrXI:519527 to 520624 | ORF Map | GBrowse
Gene Ontology Annotations All UTH1 GO evidence and references
  View Computational GO annotations for UTH1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 21 genes
Classical genetics
Large-scale survey
198 total interaction(s) for 124 unique genes/features.
Physical Interactions
  • Affinity Capture-Luminescence: 1
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 6

Genetic Interactions
  • Negative Genetic: 129
  • Phenotypic Enhancement: 18
  • Phenotypic Suppression: 10
  • Positive Genetic: 20
  • Synthetic Growth Defect: 4
  • Synthetic Lethality: 4
  • Synthetic Rescue: 3

Expression Summary
Length (a.a.) 365
Molecular Weight (Da) 36,955
Isoelectric Point (pI) 4.45
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrXI:519527 to 520624 | ORF Map | GBrowse
Last Update Coordinates: 2011-02-03 | Sequence: 2005-11-03
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..1098 519527..520624 2011-02-03 2005-11-03
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001750
References cited on this page View Complete Literature Guide for UTH1
1) Kennedy BK, et al.  (1995) Mutation in the silencing gene SIR4 can delay aging in S. cerevisiae. Cell 80(3):485-96
2) Bandara PD, et al.  (1998) Involvement of the Saccharomyces cerevisiae UTH1 gene in the oxidative-stress response. Curr Genet 34(4):259-68
3) Camougrand NM, et al.  (2000) The "SUN" family: UTH1, an ageing gene, is also involved in the regulation of mitochondria biogenesis in Saccharomyces cerevisiae. Arch Biochem Biophys 375(1):154-60
4) Velours G, et al.  (2002) Dual cell wall/mitochondria localization of the 'SUN' family proteins. FEMS Microbiol Lett 207(2):165-72
5) Kissova I, et al.  (2004) Uth1p is involved in the autophagic degradation of mitochondria. J Biol Chem 279(37):39068-74
6) Camougrand N, et al.  (2003) The product of the UTH1 gene, required for Bax-induced cell death in yeast, is involved in the response to rapamycin. Mol Microbiol 47(2):495-506
7) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
8) Ritch JJ, et al.  (2010) The Saccharomyces SUN gene, UTH1, is involved in cell wall biogenesis. FEMS Yeast Res 10(2):168-76
9) Welter E, et al.  (2013) Uth1 is a mitochondrial inner membrane protein dispensable for post-log-phase and rapamycin-induced mitophagy. FEBS J 280(20):4970-4982
10) Austriaco NR Jr  (1996) Review: to bud until death: the genetics of ageing in the yeast, Saccharomyces. Yeast 12(7):623-30