USV1/YPL230W Summary Help

Standard Name USV1 1, 2
Systematic Name YPL230W
Alias NSF1 3
Feature Type ORF, Verified
Description Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in growth on non-fermentable carbon sources, response to salt stress and cell wall biosynthesis; USV1 has a paralog, RGM1, that arose from the whole genome duplication (3, 4, 5, 6, 7)
Name Description Up in StarVation
Chromosomal Location
ChrXVI:115312 to 116487 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All USV1 GO evidence and references
  View Computational GO annotations for USV1
Molecular Function
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
Regulatory Role
Binding motifs
    Regulatory modules predicted: cellcycle (377, 311)
    Resources
    Mutant phenotypes All USV1 Phenotype evidence and references
    Classical genetics
    null
    overexpression
    Large-scale survey
    null
    Resources
    interactions All USV1 Interaction evidence and references
    23 total interaction(s) for 23 unique genes/features.
    Physical Interactions
    • Affinity Capture-RNA: 2
    Genetic Interactions
    • Negative Genetic: 15
    • Positive Genetic: 6
    Resources
    Expression Summary
    histogram
    Resources
    Protein Information All USV1 Protein evidence and references
    Localization
    Phosphorylation PhosphoGRID | PhosphoPep Database
    Structure
    Homologs
    sequence information
    ChrXVI:115312 to 116487 | ORF Map | GBrowse
    SGD ORF map
    Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
    Subfeature details
    Relative
    Coordinates    		 Chromosomal
    Coordinates    		 Most Recent Updates
    Coordinates Sequence
    5' UTR intron -93..-19 115219..115293 2007-04-04 2007-04-04
    CDS 1..1176 115312..116487 1996-07-31 1996-07-31
    Retrieve sequences
    Analyze Sequence
    S288C only
    S288C vs. other species
    S288C vs. other strains
    Resources
    External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
    Primary SGDIDS000006151
    References cited on this page View Complete Literature Guide for USV1
    1) Marchfelder U, et al.  (2003) SIR-dependent repression of non-telomeric genes in Saccharomyces cerevisiae? Yeast 20(9):797-801
    2) McCammon MT, et al.  (2003) Global transcription analysis of Krebs tricarboxylic acid cycle mutants reveals an alternating pattern of gene expression and effects on hypoxic and oxidative genes. Mol Biol Cell 14(3):958-72
    3) Hlynialuk C, et al.  (2008) Nsf1/Ypl230w participates in transcriptional activation during non-fermentative growth and in response to salt stress in Saccharomyces cerevisiae. Microbiology 154(Pt 8):2482-91
    4) Bohm S, et al.  (1997) Variations of the C2H2 zinc finger motif in the yeast genome and classification of yeast zinc finger proteins. Nucleic Acids Res 25(12):2464-9
    5) Segal E, et al.  (2003) Module networks: identifying regulatory modules and their condition-specific regulators from gene expression data. Nat Genet 34(2):166-76
    6) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
    7) Middendorf M, et al.  (2004) Predicting genetic regulatory response using classification. Bioinformatics 20 Suppl 1():i232-40
    8) Badis G, et al.  (2008) A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Mol Cell 32(6):878-87
    9) Zhu C, et al.  (2009) High-resolution DNA-binding specificity analysis of yeast transcription factors. Genome Res 19(4):556-66