Standard Name	USA1 1
Systematic Name	YML029W
Feature Type	ORF, Verified
Description	Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p (1, 2, 3)
Name Description	U1-Snp1 Associating 1

Chromosomal Location	ChrXIII:217362 to 219878 | ORF Map | GBrowse

	View Computational GO annotations for USA1
Molecular Function
Manually curated	protein complex scaffold (IDA)
Biological Process
Manually curated	ER-associated protein catabolic process (IGI, IMP, IPI) mRNA splicing, via spliceosome (IPI) positive regulation of protein oligomerization (IMP)
Cellular Component
Manually curated	endoplasmic reticulum membrane (IPI) Hrd1p ubiquitin ligase ERAD-L complex (IDA, IMP)

Classical genetics
null	6xmyc-Hmg2p accumulation: increased Der1p accumulation: decreased Sec61-2p accumulation: increased CPY* modification: absent
Large-scale survey
null	UV resistance: decreased competitive fitness: increased haploinsufficient resistance to methyl methanesulfonate: increased resistance to fenpropimorph: increased resistance to bleomycin: decreased resistance to neomycin: decreased resistance to fluconazole: decreased resistance to camptothecin: decreased resistance to cycloheximide: decreased resistance to clioquinol: decreased resistance to sorbate: increased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	131 total interaction(s) for 83 unique genes/features.
Physical Interactions	Affinity Capture-MS: 21 Affinity Capture-RNA: 4 Affinity Capture-Western: 11 Two-hybrid: 18
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 17 Phenotypic Enhancement: 29 Phenotypic Suppression: 12 Positive Genetic: 14 Synthetic Growth Defect: 3 Synthetic Lethality: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:217362 to 219878 | ORF Map | GBrowse
Last Update	Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2517 217362..219878 1996-07-31 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004491