URB1/YKL014C Summary Help

Standard Name URB1 1
Systematic Name YKL014C
Alias NPA1
Feature Type ORF, Verified
Description Protein required for the normal accumulation of 25S and 5.8S rRNAs; nucleolar protein; associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit (1, 2, 3)
Name Description Unhealthy Ribosome Biogenesis 1
Chromosomal Location
ChrXI:416913 to 411619 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All URB1 GO evidence and references
  View Computational GO annotations for URB1
Molecular Function
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 4 genes
Resources
Classical genetics
repressible
Large-scale survey
null
reduction of function
Resources
124 total interaction(s) for 99 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 108
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 1

Genetic Interactions
  • Negative Genetic: 1
  • Positive Genetic: 8
  • Synthetic Lethality: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,764
Molecular Weight (Da) 203,285
Isoelectric Point (pI) 7.31
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXI:416913 to 411619 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..5295 416913..411619 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001497
References cited on this page View Complete Literature Guide for URB1
1) Mnaimneh S, et al.  (2004) Exploration of essential gene functions via titratable promoter alleles. Cell 118(1):31-44
2) Rosado IV and de la Cruz J  (2004) Npa1p is an essential trans-acting factor required for an early step in the assembly of 60S ribosomal subunits in Saccharomyces cerevisiae. RNA 10(7):1073-83
3) Dez C, et al.  (2004) Npa1p, a component of very early pre-60S ribosomal particles, associates with a subset of small nucleolar RNPs required for peptidyl transferase center modification. Mol Cell Biol 24(14):6324-37