Standard Name	UPS2 1 (see Nomenclature conflict Note)
Systematic Name	YLR168C
Alias	MSF1' , MSF1 , AIM30 2 , GEP1 3
Feature Type	ORF, Verified
Description	Mitochondrial intermembrane space protein; involved in phospholipid metabolism; has role in regulation of phospholipid metabolism by inhibiting conversion of phosphatidylethanolamine to phosphatidylcholine; null mutant has defects in mitochondrial morphology; similar to Ups1p, Ups3p and to human PRELI; UPS2 has a paralog, UPS3, that arose from the whole genome duplication (1, 2, 3, 4, 5, 6, 7)
Name Description	UnProceSsed 6

Chromosomal Location	ChrXII:500270 to 499578 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for UPS2
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	cardiolipin metabolic process (IGI) cristae formation (IGI, IMP) negative regulation of phosphatidylcholine biosynthetic process (IMP) phosphatidylethanolamine metabolic process (IGI, IMP)
Cellular Component
Manually curated	extrinsic to mitochondrial inner membrane (IDA) mitochondrial intermembrane space (IDA)
High-throughput	mitochondrion (IDA)

Classical genetics
null	phosphatidylethanolamine accumulation: decreased mitochondrial morphology: abnormal S-Mgm1 accumulation: decreased
Large-scale survey
null	competitive fitness: decreased dessication resistance: decreased heat sensitivity: increased mitochondrial genome maintenance: abnormal respiratory growth: decreased rate vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	81 total interaction(s) for 53 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Affinity Capture-RNA: 3 Affinity Capture-Western: 4 Co-fractionation: 1
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 3 Negative Genetic: 35 Phenotypic Enhancement: 3 Phenotypic Suppression: 4 Positive Genetic: 6 Synthetic Growth Defect: 7 Synthetic Lethality: 4 Synthetic Rescue: 9
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:500270 to 499578 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..693 500270..499578 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004158