Standard Name	UPS1 1
Systematic Name	YLR193C
Feature Type	ORF, Verified
Description	Phosphatidic acid transfer protein; plays a role in phospholipid metabolism by transporting phosphatidic acid from the outer to the inner mitochondrial membrane; localizes to the mitochondrial intermembrane space; null mutant has altered cardiolipin and phosphatidic acid levels; ortholog of human PRELI (1, 2, 3, 4, 5)
Name Description	UnProceSsed 1

Chromosomal Location	ChrXII:540536 to 540009 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for UPS1
Molecular Function
Manually curated	phosphatidic acid transporter activity (IDA, IMP)
Biological Process
Manually curated	cardiolipin metabolic process (IMP) phospholipid transport (IDA, IMP) positive regulation of phosphatidylcholine biosynthetic process (IMP)
Cellular Component
Manually curated	extrinsic to mitochondrial inner membrane (IDA) mitochondrial intermembrane space (IDA)
High-throughput	mitochondrion (IDA)

Classical genetics
null	cardiolipin accumulation: decreased phosphatidylethanolamine accumulation: increased phosphatidic acid accumulation: increased chromosome/plasmid maintenance: abnormal mitochondrial morphology: abnormal Mig2p-GFP distribution: abnormal Mgm1p modification: abnormal resistance to trichothecene: increased resistance to (-)-anisomycin: increased resistance to chloramphenicol: increased vegetative growth: decreased
Large-scale survey
null	glutathione excretion: increased competitive fitness: decreased heat sensitivity: increased mitochondrial morphology: abnormal resistance to hydroxyurea: increased resistance to 4-chlorophenol: decreased resistance to dimethyl sulfoxide: increased respiratory growth: absent vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	474 total interaction(s) for 313 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 1 Affinity Capture-Western: 4 Co-fractionation: 1 Co-purification: 1
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 337 Phenotypic Enhancement: 4 Phenotypic Suppression: 6 Positive Genetic: 100 Synthetic Growth Defect: 10 Synthetic Lethality: 1 Synthetic Rescue: 8
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:540536 to 540009 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..528 540536..540009 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004183