UPS1/YLR193C Summary Help

Standard Name UPS1 1
Systematic Name YLR193C
Feature Type ORF, Verified
Description Phosphatidic acid transfer protein; plays a role in phospholipid metabolism by transporting phosphatidic acid from the outer to the inner mitochondrial membrane; localizes to the mitochondrial intermembrane space; null mutant has altered cardiolipin and phosphatidic acid levels; ortholog of human PRELI (1, 2, 3, 4, 5)
Name Description UnProceSsed 1
Chromosomal Location
ChrXII:540536 to 540009 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All UPS1 GO evidence and references
  View Computational GO annotations for UPS1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 5 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
476 total interaction(s) for 315 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 4
  • Co-fractionation: 1
  • Co-purification: 1

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 337
  • Phenotypic Enhancement: 4
  • Phenotypic Suppression: 6
  • Positive Genetic: 100
  • Synthetic Growth Defect: 10
  • Synthetic Lethality: 1
  • Synthetic Rescue: 8

Resources
Expression Summary
histogram
Resources
Length (a.a.) 175
Molecular Weight (Da) 20,108
Isoelectric Point (pI) 10.58
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:540536 to 540009 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..528 540536..540009 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004183
References cited on this page View Complete Literature Guide for UPS1
1) Sesaki H, et al.  (2006) Ups1p, a conserved intermembrane space protein, regulates mitochondrial shape and alternative topogenesis of Mgm1p. J Cell Biol 173(5):651-8
2) Osman C, et al.  (2009) The genetic interactome of prohibitins: coordinated control of cardiolipin and phosphatidylethanolamine by conserved regulators in mitochondria. J Cell Biol 184(4):583-96
3) Tamura Y, et al.  (2009) Ups1p and Ups2p antagonistically regulate cardiolipin metabolism in mitochondria. J Cell Biol 185(6):1029-45
4) Tamura Y, et al.  (2012) Role for two conserved intermembrane space proteins, Ups1p and Ups2p, [corrected] in intra-mitochondrial phospholipid trafficking. J Biol Chem 287(19):15205-18
5) Connerth M, et al.  (2012) Intramitochondrial transport of phosphatidic acid in yeast by a lipid transfer protein. Science 338(6108):815-8