UPF3/YGR072W Summary Help

UPF3 BASIC INFORMATION

Standard Name UPF3 1
Systematic Name YGR072W
Alias SUA6 2 , SUP112 3
Feature Type ORF, Verified
Description Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance (1, 4, 5)
Name Description UP Frameshift
GO Annotations All UPF3 GO evidence and references
    View Computational GO annotations for UPF3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All UPF3 Phenotype details and references
Classical genetics
null
Large-scale survey
null
overexpression
Interactions UPF3 All interactions details and references
62 total interaction(s) for 50 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 2
  • Reconstituted Complex: 1
  • Two-hybrid: 4
Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 1
  • Phenotypic Enhancement: 14
  • Phenotypic Suppression: 26
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 4
  • Synthetic Rescue: 4
Sequence Information
ChrVII:634308 to 635471 | ORF Map | GBrowse
Gbrowse
Genetic position: 32 cM
Last Update Coordinates: 2004-07-20 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1164 634308..635471 2004-07-20 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000003304

UPF3 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for UPF3

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for UPF3]

1) Leeds P, et al.  (1992) Gene products that promote mRNA turnover in Saccharomyces cerevisiae. Mol Cell Biol 12(5):2165-77
2) Hampsey M, et al.  (1991) Extragenic suppressors of a translation initiation defect in the cyc1 gene of Saccharomyces cerevisiae. Biochimie 73(12):1445-55
3) Ono B, et al.  (2005) Suppression of termination mutations caused by defects of the NMD machinery in Saccharomyces cerevisiae. Genes Genet Syst 80(5):311-6
4) He F, et al.  (1997) Upf1p, Nmd2p, and Upf3p are interacting components of the yeast nonsense-mediated mRNA decay pathway. Mol Cell Biol 17(3):1580-94
5) Askree SH, et al.  (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63