Standard Name	UPF3 1
Systematic Name	YGR072W
Alias	SUA6 2 , SUP112 3
Feature Type	ORF, Verified
Description	Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance (1, 4, 5)
Name Description	UP Frameshift

Chromosomal Location	ChrVII:634304 to 635467 | ORF Map | GBrowse
	Genetic position: 32 cM

	View Computational GO annotations for UPF3
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay (IGI) protein ubiquitination (IMP, IPI) NOT translational frameshifting (IMP)
Cellular Component
Manually curated	cytoplasm (IDA) nucleolus (IDA) nucleus (IDA) polysome (IDA)

Classical genetics
null	PGK1(N103)pG mRNA accumulation: increased Nmd2p distribution: abnormal Dcp2p distribution: abnormal
Large-scale survey
null	acid pH resistance: decreased competitive fitness: decreased resistance to caffeine: increased resistance to sodium arsenite: increased resistance to arsenite(3-): increased resistance to PM02734: increased resistance to cisplatin: increased resistance to cycloheximide: decreased resistance to methyl methanesulfonate: decreased resistance to boric acid: decreased resistance to L-canavanine: increased resistance to tunicamycin: increased telomere length: decreased transposable element transposition: decreased viable
overexpression	resistance to sirolimus: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	163 total interaction(s) for 120 unique genes/features.
Physical Interactions	Affinity Capture-MS: 5 Affinity Capture-RNA: 1 Affinity Capture-Western: 2 Reconstituted Complex: 1 Two-hybrid: 4
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 1 Negative Genetic: 77 Phenotypic Enhancement: 3 Phenotypic Suppression: 2 Positive Genetic: 50 Synthetic Growth Defect: 6 Synthetic Lethality: 3 Synthetic Rescue: 7
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:634304 to 635467 | ORF Map | GBrowse
	Genetic position: 32 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1164 634304..635467 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003304