UPC2/YDR213W Summary Help

Standard Name UPC2 1
Systematic Name YDR213W
Alias MOX4 2
Feature Type ORF, Verified
Description Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication (2, 3, 4, 5, 6, 7, 8, 9, 10)
Name Description UPtake Control 1, 3
Chromosomal Location
ChrIV:889751 to 892492 | ORF Map | GBrowse
Gene Ontology Annotations All UPC2 GO evidence and references
  View Computational GO annotations for UPC2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Targets 3 genes
Regulators 3 genes
Classical genetics
Large-scale survey
112 total interaction(s) for 94 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 8
  • Affinity Capture-RNA: 1
  • Two-hybrid: 2

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Lethality: 1
  • Negative Genetic: 55
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 14
  • Positive Genetic: 14
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 10
  • Synthetic Rescue: 2

Expression Summary
Length (a.a.) 913
Molecular Weight (Da) 100,339
Isoelectric Point (pI) 5.9
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrIV:889751 to 892492 | ORF Map | GBrowse
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..2742 889751..892492 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002621
References cited on this page View Complete Literature Guide for UPC2
1) Lewis TL, et al.  (1988) Pleiotropic mutations in Saccharomyces cerevisiae affecting sterol uptake and metabolism. Yeast 4(2):93-106
2) Abramova NE, et al.  (2001) Regulatory mechanisms controlling expression of the DAN/TIR mannoprotein genes during anaerobic remodeling of the cell wall in Saccharomyces cerevisiae. Genetics 157(3):1169-77
3) Crowley JH, et al.  (1998) A mutation in a purported regulatory gene affects control of sterol uptake in Saccharomyces cerevisiae. J Bacteriol 180(16):4177-83
4) Shianna KV, et al.  (2001) Identification of a UPC2 homolog in Saccharomyces cerevisiae and its involvement in aerobic sterol uptake. J Bacteriol 183(3):830-4
5) Abramova NE, et al.  (2001) Reciprocal regulation of anaerobic and aerobic cell wall mannoprotein gene expression in Saccharomyces cerevisiae. J Bacteriol 183(9):2881-7
6) Vik A and Rine J  (2001) Upc2p and Ecm22p, dual regulators of sterol biosynthesis in Saccharomyces cerevisiae. Mol Cell Biol 21(19):6395-405
7) Kwast KE, et al.  (2002) Genomic analyses of anaerobically induced genes in Saccharomyces cerevisiae: functional roles of Rox1 and other factors in mediating the anoxic response. J Bacteriol 184(1):250-65
8) Wilcox LJ, et al.  (2002) Transcriptional profiling identifies two members of the ATP-binding cassette transporter superfamily required for sterol uptake in yeast. J Biol Chem 277(36):32466-72
9) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
10) Marie C, et al.  (2008) Cytoplasmic localization of sterol transcription factors Upc2p and Ecm22p in S. cerevisiae. Fungal Genet Biol 45(10):1430-8