UMP1/YBR173C Summary Help

Standard Name UMP1 1
Systematic Name YBR173C
Alias RNS2 2
Feature Type ORF, Verified
Description Chaperone required for correct maturation of the 20S proteasome; short-lived chaperone; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly (1, 3, 4, 5)
Name Description Ubiquitin-Mediated Proteolysis 1
Chromosomal Location
ChrII:582172 to 581726 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All UMP1 GO evidence and references
  View Computational GO annotations for UMP1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 5 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
Resources
134 total interaction(s) for 103 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 31
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 8
  • Biochemical Activity: 1
  • Co-fractionation: 2
  • Co-localization: 3
  • Co-purification: 1
  • Two-hybrid: 3

Genetic Interactions
  • Dosage Growth Defect: 2
  • Dosage Rescue: 1
  • Negative Genetic: 42
  • Phenotypic Enhancement: 3
  • Phenotypic Suppression: 6
  • Positive Genetic: 7
  • Synthetic Growth Defect: 8
  • Synthetic Lethality: 7
  • Synthetic Rescue: 6

Resources
Expression Summary
histogram
Resources
Length (a.a.) 148
Molecular Weight (Da) 16,760
Isoelectric Point (pI) 4.87
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:582172 to 581726 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..447 582172..581726 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000377
References cited on this page View Complete Literature Guide for UMP1
1) Ramos PC, et al.  (1998) Ump1p is required for proper maturation of the 20S proteasome and becomes its substrate upon completion of the assembly. Cell 92(4):489-99
2) Ishikawa T, et al.  (2005) Isolation of Saccharomyces cerevisiae RNase T1 hypersensitive (rns) mutants and genetic analysis of the RNS1/DSL1 gene. J Gen Appl Microbiol 51(1):73-82
3) Maurizi MR  (1998) Proteasome assembly: biting the hand. Curr Biol 8(13):R453-6
4) Bochtler M, et al.  (1999) The proteasome. Annu Rev Biophys Biomol Struct 28:295-317
5) Li X, et al.  (2007) beta-Subunit appendages promote 20S proteasome assembly by overcoming an Ump1-dependent checkpoint. EMBO J 26(9):2339-49