UME1/YPL139C Summary Help

Standard Name UME1 1
Systematic Name YPL139C
Alias WTM3 2
Feature Type ORF, Verified
Description Negative regulator of meiosis; required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif; homologous with Wtm1p; UME1 has a paralog, WTM2, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description Unscheduled Meiotic gene Expression 1
Chromosomal Location
ChrXVI:291051 to 289669 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All UME1 GO evidence and references
  View Computational GO annotations for UME1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulatory Role
Binding motifs Predicted UME1 Binding Site Locations
    Regulatory modules predicted: stressResponse (547, 535, 487)
    Resources
    Mutant phenotypes All UME1 Phenotype evidence and references
    Classical genetics
    null
    Large-scale survey
    null
    Resources
    interactions All UME1 Interaction evidence and references
    249 total interaction(s) for 155 unique genes/features.
    Physical Interactions
    • Affinity Capture-MS: 80
    • Affinity Capture-RNA: 1
    • Affinity Capture-Western: 8
    • Biochemical Activity: 5
    • PCA: 3
    • Protein-peptide: 1
    • Reconstituted Complex: 2
    Genetic Interactions
    • Negative Genetic: 119
    • Positive Genetic: 27
    • Synthetic Growth Defect: 3
    Resources
    Expression Summary
    histogram
    Resources
    Protein Information All UME1 Protein evidence and references
    Localization
    Phosphorylation PhosphoGRID | PhosphoPep Database
    Structure
    Homologs
    sequence information
    ChrXVI:291051 to 289669 | ORF Map | GBrowse
    Note: this feature is encoded on the Crick strand.
    SGD ORF map
    Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
    Subfeature details
    Relative
    Coordinates    		 Chromosomal
    Coordinates    		 Most Recent Updates
    Coordinates Sequence
    CDS 1..1383 291051..289669 2011-02-03 1996-07-31
    Retrieve sequences
    Analyze Sequence
    S288C only
    S288C vs. other species
    S288C vs. other strains
    Resources
    External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
    Primary SGDIDS000006060
    References cited on this page View Complete Literature Guide for UME1
    1) Strich R, et al.  (1989) Identification of negative regulatory genes that govern the expression of early meiotic genes in yeast. Proc Natl Acad Sci U S A 86(24):10018-22
    2) Pemberton LF and Blobel G  (1997) Characterization of the Wtm proteins, a novel family of Saccharomyces cerevisiae transcriptional modulators with roles in meiotic regulation and silencing. Mol Cell Biol 17(8):4830-41
    3) Kurdistani SK, et al.  (2002) Genome-wide binding map of the histone deacetylase Rpd3 in yeast. Nat Genet 31(3):248-54
    4) Mallory MJ and Strich R  (2003) Ume1p represses meiotic gene transcription in Saccharomyces cerevisiae through interaction with the histone deacetylase Rpd3p. J Biol Chem 278(45):44727-34
    5) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61