ULP1/YPL020C Summary Help

Standard Name ULP1 1
Systematic Name YPL020C
Alias NIB1 2
Feature Type ORF, Verified
Description Protease that specifically cleaves Smt3p protein conjugates; required for cell cycle progression; associates with nucleoporins and may interact with septin rings during telophase; sequestered to the nucleolus under stress conditions (3, 4, 5, 6)
Name Description UbL-specific Protease 1
Chromosomal Location
ChrXVI:514178 to 512313 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All ULP1 GO evidence and references
  View Computational GO annotations for ULP1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Resources
Classical genetics
conditional
null
reduction of function
Large-scale survey
null
overexpression
reduction of function
Resources
328 total interaction(s) for 254 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 71
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 11
  • Biochemical Activity: 1
  • Co-crystal Structure: 1
  • PCA: 124
  • Reconstituted Complex: 4
  • Two-hybrid: 27

Genetic Interactions
  • Dosage Rescue: 13
  • Negative Genetic: 21
  • Phenotypic Enhancement: 4
  • Phenotypic Suppression: 1
  • Synthetic Growth Defect: 8
  • Synthetic Lethality: 29
  • Synthetic Rescue: 10

Resources
Expression Summary
histogram
Resources
Length (a.a.) 621
Molecular Weight (Da) 72,377
Isoelectric Point (pI) 10.27
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:514178 to 512313 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1866 514178..512313 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005941
References cited on this page View Complete Literature Guide for ULP1
1) Li SJ and Hochstrasser M  (1999) A new protease required for cell-cycle progression in yeast. Nature 398(6724):246-51
2) Dobson MJ, et al.  (2005) The 2 microm plasmid causes cell death in Saccharomyces cerevisiae with a mutation in Ulp1 protease. Mol Cell Biol 25(10):4299-310
3) Hochstrasser M  (2001) SP-RING for SUMO: new functions bloom for a ubiquitin-like protein. Cell 107(1):5-8
4) Li SJ and Hochstrasser M  (2003) The Ulp1 SUMO isopeptidase: distinct domains required for viability, nuclear envelope localization, and substrate specificity. J Cell Biol 160(7):1069-81
5) Soustelle C, et al.  (2004) A new Saccharomyces cerevisiae strain with a mutant Smt3-deconjugating Ulp1 protein is affected in DNA replication and requires Srs2 and homologous recombination for its viability. Mol Cell Biol 24(12):5130-43
6) Sydorskyy Y, et al.  (2010) A Novel Mechanism for SUMO System Control: Regulated Ulp1 Nucleolar Sequestration. Mol Cell Biol 30(18):4452-62