Standard Name	UFE1 1
Systematic Name	YOR075W
Feature Type	ORF, Verified
Description	t-SNARE required for retrograde vesicular traffic and homotypic ER membrane fusion; forms a complex with the SNAREs Sec22p, Sec20p and Use1p to mediate fusion of Golgi-derived vesicles at the ER (1, 2, 3, 4) Also known as: YOR29-26
Name Description	Unknown Function Essential 1

Chromosomal Location	ChrXV:468212 to 469252 | ORF Map | GBrowse

	View Computational GO annotations for UFE1
Molecular Function
Manually curated	SNAP receptor activity (ISA)
Biological Process
Manually curated	endoplasmic reticulum membrane fusion (IMP) retrograde vesicle-mediated transport, Golgi to ER (IMP) vesicle fusion with endoplasmic reticulum (IC, NAS)
Cellular Component
Manually curated	endoplasmic reticulum (IDA) integral to membrane (ISM) SNARE complex (IDA)

Classical genetics
conditional	endoplasmic reticulum morphology: abnormal heat sensitivity: increased
null	inviable
Large-scale survey
null	inviable resistance to sirolimus: decreased resistance to wortmannin: normal starvation resistance: decreased
reduction of function	competitive fitness: increased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	71 total interaction(s) for 28 unique genes/features.
Physical Interactions	Affinity Capture-MS: 15 Affinity Capture-RNA: 1 Affinity Capture-Western: 17 Biochemical Activity: 1 PCA: 1 Reconstituted Complex: 9 Two-hybrid: 6
Genetic Interactions	Dosage Growth Defect: 1 Dosage Rescue: 7 Negative Genetic: 1 Phenotypic Enhancement: 1 Phenotypic Suppression: 6 Synthetic Growth Defect: 1 Synthetic Lethality: 3 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:468212 to 469252 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1041 468212..469252 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005601