Standard Name	UFD4 1
Systematic Name	YKL010C
Feature Type	ORF, Verified
Description	Ubiquitin-protein ligase (E3); interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins; relative distribution to the nucleus increases upon DNA replication stress (2, 3, 4, 5)
Name Description	Ubiquitin Fusion Degradation protein 1

Chromosomal Location	ChrXI:425875 to 421424 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for UFD4
Molecular Function
Manually curated	ubiquitin-protein ligase activity (TAS)
Biological Process
Manually curated	protein monoubiquitination (TAS) protein polyubiquitination (TAS)
Cellular Component
Manually curated	cytoplasm (IPI)
High-throughput	cytoplasm (IDA) mitochondrion (IDA) nucleus (IDA)

Classical genetics
null	Matalpha1p accumulation: increased resistance to 2-deoxy-D-glucose: increased resistance to (S)-azetidine-2-carboxylic acid: increased
Large-scale survey
null	chitin deposition: decreased competitive fitness: increased dessication resistance: decreased haploinsufficient resistance to Calcofluor White: increased resistance to 4-chlorophenol: decreased sporulation efficiency: increased viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	80 total interaction(s) for 59 unique genes/features.
Physical Interactions	Affinity Capture-MS: 26 Affinity Capture-RNA: 2 Affinity Capture-Western: 11 Biochemical Activity: 1 PCA: 2 Reconstituted Complex: 4 Two-hybrid: 3
Genetic Interactions	Negative Genetic: 13 Phenotypic Enhancement: 3 Phenotypic Suppression: 1 Positive Genetic: 8 Synthetic Growth Defect: 3 Synthetic Lethality: 1 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXI:425875 to 421424 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..4452 425875..421424 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001493