Standard Name	UBR2
Systematic Name	YLR024C
Feature Type	ORF, Verified
Description	Cytoplasmic ubiquitin-protein ligase (E3); required for ubiquitylation of Rpn4p; mediates formation of a Mub1p-Ubr2p-Rad6p complex (1, 2, 3)

Chromosomal Location	ChrXII:193281 to 187663 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for UBR2
Molecular Function
Manually curated	ubiquitin-protein ligase activity (TAS)
Biological Process
Manually curated	protein monoubiquitination (IDA)
Cellular Component
High-throughput	cytoplasm (IDA)

Classical genetics
null	PTR2 mRNA accumulation: increased PMA1 mRNA accumulation: increased heat sensitivity: decreased metal resistance: increased oxidative stress resistance: decreased proteasome holocomplex activity: increased delta2GFP accumulation: decreased Htt103Q-CFP accumulation: decreased proteasome subunits accumulation: increased Ptr2p-GFP accumulation: increased Mub1p accumulation: increased Rpn4p accumulation: increased Rpn4p modification: absent replicative lifespan: increased resistance to L-canavanine: increased resistance to tunicamycin: increased resistance to methyl methanesulfonate: increased small molecule transport: increased
Large-scale survey
null	glycogen accumulation: increased competitive fitness: increased haploinsufficient lifespan: increased nutrient utilization: increased Rpn4p11-229-His3 accumulation: increased resistance to oleate: decreased resistance to arsenite(3-): decreased resistance to bleomycin: decreased resistance to mycophenolic acid: increased resistance to quinine: increased resistance to tacrolimus (anhydrous) and tunicamycin: increased resistance to 1,4-dithiothreitol and tacrolimus (anhydrous): increased resistance to caffeine: increased resistance to tunicamycin: increased resistance to fluconazole: increased sporulation: normal sporulation efficiency: increased stress resistance: increased toxin resistance: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	185 total interaction(s) for 141 unique genes/features.
Physical Interactions	Affinity Capture-MS: 20 Affinity Capture-RNA: 1 Affinity Capture-Western: 6 Biochemical Activity: 1 Reconstituted Complex: 2 Two-hybrid: 4
Genetic Interactions	Dosage Lethality: 1 Negative Genetic: 99 Phenotypic Suppression: 1 Positive Genetic: 45 Synthetic Growth Defect: 2 Synthetic Lethality: 1 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:193281 to 187663 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..5619 193281..187663 2011-02-03 2011-02-03
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004014