Standard Name	UBP14 1
Systematic Name	YBR058C
Alias	GID6 2
Feature Type	ORF, Verified
Description	Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T (1, 2, 3)
Name Description	UBiquitin-specific Protease 1

Chromosomal Location	ChrII:356017 to 353672 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for UBP14
Molecular Function
Manually curated	ubiquitin-specific protease activity (IDA)
Biological Process
Manually curated	negative regulation of gluconeogenesis (IMP) proteasomal ubiquitin-dependent protein catabolic process (IMP)
Cellular Component
Manually curated	cytoplasm (IC)

Classical genetics
null	PTR2 mRNA accumulation: decreased Fbp1p accumulation: increased Ptr2p-GFP accumulation: decreased resistance to canavanine sulfate: decreased small molecule transport: decreased
Large-scale survey
null	auxotrophy competitive fitness: decreased dessication resistance: decreased nutrient utilization: decreased resistance to tunicamycin: increased resistance to camptothecin: increased resistance to tunicamycin: decreased resistance to sirolimus: increased resistance to wortmannin: decreased resistance to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO): decreased resistance to methyl methanesulfonate: decreased resistance to bleomycin: decreased resistance to fluconazole: decreased resistance to L-1,4-dithiothreitol: decreased resistance to selenomethionine: increased resistance to benzo[a]pyrene: decreased sporulation: decreased stress resistance: increased toxin resistance: increased toxin resistance: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	162 total interaction(s) for 127 unique genes/features.
Physical Interactions	Affinity Capture-MS: 19
Genetic Interactions	Dosage Growth Defect: 6 Negative Genetic: 99 Phenotypic Enhancement: 1 Phenotypic Suppression: 1 Positive Genetic: 11 Synthetic Growth Defect: 18 Synthetic Lethality: 5 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrII:356017 to 353672 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 2003-09-22
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2346 356017..353672 2011-02-03 2003-09-22
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000262