UBP1/YDL122W Summary

UBP1 BASIC INFORMATION

Standard Name	UBP1 1
Systematic Name	YDL122W
Feature Type	ORF, Verified
Description	Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains (1, 2)
Name Description	UBiquitin-specific Protease 1

GO Annotations	All UBP1 GO evidence and references
	View Computational GO annotations for UBP1
Molecular Function
Manually curated	ubiquitin-specific protease activity (IDA)
Biological Process
Manually curated	protein deubiquitination (TAS)
Cellular Component
Manually curated	cytoplasm (IC, IDA) endoplasmic reticulum (IDA)

Mutant Phenotype	All UBP1 Phenotype details and references
Large-scale survey
null	competitive fitness: decreased resistance to rapamycin: increased resistance to wortmannin: normal resistance to nickel sulfate: increased sporulation: normal viable

Interactions	UBP1 All interactions details and references
	View additional details at BioGRID
	122 total interaction(s) for 98 unique genes/features.
Physical Interactions	Affinity Capture-MS: 5 Affinity Capture-RNA: 1 Biochemical Activity: 5 Two-hybrid: 1
Genetic Interactions	Negative Genetic: 103 Phenotypic Enhancement: 1 Phenotypic Suppression: 1 Positive Genetic: 3 Synthetic Growth Defect: 1 Synthetic Lethality: 1

Sequence Information

ChrIV:242552 to 244981 | |

Last Update

Coordinates: 2004-02-11 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2430	242552..244981	2004-02-11	1996-07-31

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000002280

UBP1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for UBP1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for UBP1]

1)	Tobias JW and Varshavsky A (1991) Cloning and functional analysis of the ubiquitin-specific protease gene UBP1 of Saccharomyces cerevisiae. J Biol Chem 266(18):12021-8
2)	Baker RT, et al. (1992) Ubiquitin-specific proteases of Saccharomyces cerevisiae. Cloning of UBP2 and UBP3, and functional analysis of the UBP gene family. J Biol Chem 267(32):23364-75

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