UBC9/YDL064W Summary Help

Standard Name UBC9 1
Systematic Name YDL064W
Feature Type ORF, Verified
Description SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC) (1, 2, 3)
Name Description UBiquitin-Conjugating 1
Chromosomal Location
ChrIV:337487 to 338070 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All UBC9 GO evidence and references
  View Computational GO annotations for UBC9
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 2 genes
Resources
Classical genetics
activation
conditional
reduction of function
repressible
Large-scale survey
conditional
null
repressible
Resources
207 total interaction(s) for 150 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 101
  • Affinity Capture-RNA: 4
  • Affinity Capture-Western: 6
  • Biochemical Activity: 10
  • Co-crystal Structure: 2
  • PCA: 2
  • Reconstituted Complex: 13
  • Two-hybrid: 38

Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 1
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 1
  • Synthetic Growth Defect: 7
  • Synthetic Lethality: 14
  • Synthetic Rescue: 5

Resources
Expression Summary
histogram
Resources
Length (a.a.) 157
Molecular Weight (Da) 17,911
Isoelectric Point (pI) 9.98
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:337487 to 338070 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2004-02-11 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..38 337487..337524 2004-02-11 1996-07-31
Intron 39..148 337525..337634 2004-02-11 1996-07-31
CDS 149..584 337635..338070 2004-02-11 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002222
References cited on this page View Complete Literature Guide for UBC9
1) Seufert W, et al.  (1995) Role of a ubiquitin-conjugating enzyme in degradation of S- and M-phase cyclins. Nature 373(6509):78-81
2) Johnson ES and Blobel G  (1997) Ubc9p is the conjugating enzyme for the ubiquitin-like protein Smt3p. J Biol Chem 272(43):26799-802
3) Dieckhoff P, et al.  (2004) Smt3/SUMO and Ubc9 are required for efficient APC/C-mediated proteolysis in budding yeast. Mol Microbiol 51(5):1375-87