UBC7/YMR022W Summary Help

Standard Name UBC7 1
Systematic Name YMR022W
Alias QRI8 2 , DER2 3
Feature Type ORF, Verified
Description Ubiquitin conjugating enzyme; involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly (4, 5)
Name Description UBiquitin-Conjugating enzyme 1
Chromosomal Location
ChrXIII:318680 to 319177 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All UBC7 GO evidence and references
  View Computational GO annotations for UBC7
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 4 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
Resources
350 total interaction(s) for 170 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 7
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 12
  • Biochemical Activity: 4
  • Co-crystal Structure: 1
  • Co-purification: 1
  • Reconstituted Complex: 14
  • Two-hybrid: 2

Genetic Interactions
  • Dosage Growth Defect: 2
  • Dosage Lethality: 2
  • Dosage Rescue: 2
  • Negative Genetic: 153
  • Phenotypic Enhancement: 37
  • Phenotypic Suppression: 29
  • Positive Genetic: 57
  • Synthetic Growth Defect: 10
  • Synthetic Lethality: 7
  • Synthetic Rescue: 7

Resources
Expression Summary
histogram
Resources
Length (a.a.) 165
Molecular Weight (Da) 18,520
Isoelectric Point (pI) 4.9
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:318680 to 319177 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..498 318680..319177 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004624
References cited on this page View Complete Literature Guide for UBC7
1) Jungmann J, et al.  (1993) Resistance to cadmium mediated by ubiquitin-dependent proteolysis. Nature 361(6410):369-71
2) Vassal A, et al.  (1992) QRI8, a novel ubiquitin-conjugating enzyme in Saccharomyces cerevisiae. Biochim Biophys Acta 1132(2):211-3
3) Hiller MM, et al.  (1996) ER degradation of a misfolded luminal protein by the cytosolic ubiquitin-proteasome pathway. Science 273(5282):1725-8
4) Biederer T, et al.  (1997) Role of Cue1p in ubiquitination and degradation at the ER surface. Science 278(5344):1806-9
5) Arnason TG, et al.  (2005) Novel interaction between Apc5p and Rsp5p in an intracellular signaling pathway in Saccharomyces cerevisiae. Eukaryot Cell 4(1):134-46