UBC5/YDR059C Summary Help

UBC5 BASIC INFORMATION

Standard Name UBC5
Systematic Name YDR059C
Feature Type ORF, Verified
Description Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived, abnormal, or excess proteins, including histone H3; central component of the cellular stress response; expression is heat inducible (1, 2, 3 and see Summary Paragraph)
Name Description UBiquitin-Conjugating
GO Annotations All UBC5 GO evidence and references
    View Computational GO annotations for UBC5
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All UBC5 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions UBC5 All interactions details and references
31 total interaction(s) for 20 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-Western: 2
  • Biochemical Activity: 4
  • Co-purification: 1
  • Two-hybrid: 4
Genetic Interactions
  • Phenotypic Enhancement: 12
  • Phenotypic Suppression: 4
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 2
Sequence Information
ChrIV:569769 to 569233 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2008-06-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..47 569769..569723 2008-06-05 1996-07-31
Intron 48..137 569722..569633 2008-06-05 1996-07-31
CDS 138..537 569632..569233 2008-06-05 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000002466

UBC5 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Protein Info & Structure
  • Localization Resources
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  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for UBC5

SUMMARY PARAGRAPH for UBC5

UBC5 encodes a ubiquitin conjugating enzyme that links ubiquitin (Ubi4p) to lysine residues of target proteins (1, 4). Ubc5p plays a role in protein polyubiquitination (1), acts as a central component of the cellular stress response (2) and is also involved in sporulation (4). Ubc5p is associated with the proteasome complex (5). A related ubiquitin conjugating enzyme, (UBC4), shows strong sequence similarity to UBC5 and both are complementary in function (1). Together, Ubc5p and Ubc4p mediate the selective degradation of short-lived and abnormal proteins. Loss of UBC4 and UBC5 results in cell growth defects, temperature sensitivity, inviability in the presence of an amino acid analog, and the induction of the stress response (1).

Last updated: 2005-05-24

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for UBC5]

1) Seufert W and Jentsch S  (1990) Ubiquitin-conjugating enzymes UBC4 and UBC5 mediate selective degradation of short-lived and abnormal proteins. EMBO J 9(2):543-50
2) Seufert W and Jentsch S  (1991) Yeast ubiquitin-conjugating enzymes involved in selective protein degradation are essential for cell viability. Acta Biol Hung 42(1-3):27-37
3) Singh RK, et al.  (2009) Histone levels are regulated by phosphorylation and ubiquitylation-dependent proteolysis. Nat Cell Biol 11(8):925-33
4) Hochstrasser M  (1996) Ubiquitin-dependent protein degradation. Annu Rev Genet 30:405-39
5) Tongaonkar P, et al.  (2000) Evidence for an interaction between ubiquitin-conjugating enzymes and the 26S proteasome. Mol Cell Biol 20(13):4691-8